The main objective is to determine the origin of somatosensory alteration in patients with ALS and to evaluate its impact on brain activity by coupling different imaging modalities and indirect electrophysiology. The secondary objective is to evaluate whether the observed functional changes in MEG / EEG and functional MRI correlate with structural lesions revealed with diffusion MRI (anatomo-functional connectivity of the brain).
Somatosensory evoked potentials (SEPs) produced by ulnar nerve electrical stimulation will be collected with combined MEG and EGG. Functional MRI will be performed during electrical stimulation of ulnar nerve and during mechanical vibration of ADM tendon. Brain diffusion MRI will be performed. Anatomical MRI will be done for source location. Brain resting state activity will be recorded with MEG/EEG and fMRI.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
52
conditioning brain activity with peripheral stimulations
diffusion MRI and tractography for evaluating the brain structures
conditioning brain activity with peripheral stimulations
Hopital Pitie-Salpetriere
Paris, France
Brain activity
Brain parametric maps
Time frame: 1 hour
Brain connectivity
diffusion brain MRI (tractography)
Time frame: 15 min
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