Parathyroid hormone (PTH) may play an important role in the down-regulation of CYP3A4 expression induced by Chronic kidney diseases (CKD). In the study of molecular mechanism, the research group found that the expression of CYP3A2 metabolic enzyme in rat liver decreased in the state of CKD.And PTH may down-regulate the expression of CYP3A4 metabolic enzyme by inhibiting the expression of Nuclear factor- Kilobuse (NF-kB) p65 subunit
Study Type
OBSERVATIONAL
Enrollment
200
lower blood pressure
The Third Xiangya Hospital of Central South University , , China,
Changsha, Hunan, China
RECRUITINGthe concentration of nifedipine
the concentration of nifedipine
Time frame: at 5-7days
24-hour ambulatory blood pressure
mean blood pressure
Time frame: at 1 day and 7day
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