This is a prospective crossover study to compare the within-subject effect of the two target ranges of arterial oxygen saturation (SpO2), both within the clinically recommended range of 90- 95%. The specific objective of this study to evaluate the impact of targeting SpO2 within 93-95% compared to the 90-92% range on ventilatory stability in premature infants of 23-29 weeks gestational age (GA).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
19
FiO2 adjusted to keep basal SpO2 at target range of 93-95% for 2 hours
FiO2 adjusted to keep basal SpO2 at target range of 90-92% for 2 hours.
Holtz Children's Hospital
Miami, Florida, United States
ventilatory stability by frequency of central apnea
by frequency of central apnea
Time frame: 2 hours
ventilatory stability by frequency of obstructive apnea
by frequency of obstructive apnea
Time frame: 2 hours
ventilatory stability by density of periodic breathing
by density of periodic breathing
Time frame: 2 hours
ventilatory stability by time series of inter-breath intervals
by time series of inter-breath intervals
Time frame: 2 hours
oxygenation stability by frequency of intermittent hypoxemia episodes
frequency of episodes with SpO2 \< 80%
Time frame: 2 hours
frequency of bradycardia episodes
frequency of episodes with HR \< 100 bpm
Time frame: 2 hours
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