Study to Assess the Safety and Efficacy of an IT Administration of SCM-010 in SPMS

Inclusion Criteria: 1. Male or female subjects (18-60 years of age) diagnosed with SPMS. 2. SPMS defined as relapsing-remitting disease followed by progression of disability independent of or not explained by multiple sclerosis (MS) relapses for at least 2 years. 3. Subjects should be ambulatory with an EDSS score of 3-6.5 (inclusive) at screening and baseline visits. 4. Subjects should be able to go through a lipoaspiration procedure, evaluated by the study's plastic surgeon. 5. Women capable of child bearing must have a negative urine pregnancy test at screening and baseline visits. 6. Subjects must use an adequate contraceptive method throughout the study. 7. Coagulation tests including INR, PTT and prothrombin time (PT) within normal range. 8. Subjects must be willing and able to comply with the protocol requirements for the duration of the study. 9. Ability to provide written informed consent. Exclusion Criteria: 1. Relapsing remitting multiple sclerosis (RRMS) or primary progressive multiple sclerosis (PPMS) as defined by the revised McDonald criteria. 2. Any chronic central nervous system (CNS) disease other than SPMS. 3. Clinical relapse within 3 months prior to study entry. 4. Subjects diagnosed with any systemic autoimmune disease. 5. Contraindications or inability to undergo lumbar puncture (LP) procedure and or intrathecal administration. 6. Severe anemia (hemoglobin \< 10 g/dL). 7. Abnormal renal function (serum creatinine more than 1.5xULN or creatinine clearance \<30 ml/min). 8. Tested positive for HIV, hepatitis (HBV and HCV). 9. Known as positive for VDRL and/or tuberculosis. 10. Active malignant disease of any kind. However, a patient, who has had a malignant disease in the past, was treated and is currently disease - free for at least 7 years, may be considered eligible. In this case the sponsor medical expert approval is required. 11. Previous cell therapy treatment. 12. Previous total body irradiation or total lymphoid irradiation. 13. Previous use of natalizumab or any anti-B cell agent within 6 months prior to screening. 14. Previous use of immunosuppressant including Mitoxantrone, Alemtuzumab, Cladribine or any other cytotoxic agent. 15. Previous use of Fingolimod or Dimethyl Fumarate within 2 months prior to screening. Subjects who were treated with any of these medications will be excluded if they do not have a lymphocyte count within normal range at screening. 16. Previous use of Teriflunomide within 12 months if no accelerated elimination procedure was used. 17. Previous treatment with immunomodulators (including IFNβ 1a and 1b, and IV Immunoglobulin (IVIG) or Glatiramer Acetate (GA) within 2 months prior to screening. 18. A known history of hypersensitivity to one of following: Vancomycin, Cephalosporin, Cephamycin or beta-lactam antibacterial agent (penicillins, monobactams, carbapenems). 19. A known history of sensitivity to Gadolinium. 20. Inability to successfully undergo MRI scanning. 21. Treatment with any kind of steroids or ACTH during the last 30 days prior to screening. 22. Subjects with clotting disorders or receiving treatment with anticoagulants. 23. Any relevant medical, surgical, or psychiatric condition, laboratory value, or concomitant medication which, in the opinion of the Principle Investigator, makes the subject unsuitable for study entry or potentially unable to complete all aspects of the study. 24. Subjects with BMI \< 20. 25. Pregnant or breast-feeding women. 26. Known or suspected drug or alcohol abuse. 27. Participation in any investigational drug study within 6 months prior to screening.