Photodynamic Therapy of Actinic Keratosis of the Face and Scalp With and Without Prior Curettage

Bispebjerg Hospital25 enrolled

Overview

Guidelines for photodynamic therapy (PDT) of actinic keratosis recommend pretreatment with curettage. The impact of curettage on the treatment effect is, however, not known. The present study aimed to evaluate whether daylight-PDT without curettage would reduce treatment effect compared to daylight-PDT with curettage.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Keratosis, Actinic

Interventions

No curettageDRUG

Standard PDT without curettage

CurettageDRUG

Standard PDT

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- Multiple actinic keratosis on the forehead or scalp Exclusion Criteria: * Known allergy to methyl aminolevulinate * Porphyria * Pregnancy * Lactation

Locations (1)

Bispebjerg Hospital

Copenhagen NV, DK, Denmark

Outcomes

Primary Outcomes

Complete lesion response rate

Complete lesion response rate, was defined as the number of completely responding lesions divided by the total number of treated lesion in each field. Complete lesion response was defined as complete disappearance of the lesion both by palpation and visually.

Time frame: Treatment efficacy was evaluated 3 months after PDT

Data from ClinicalTrials.gov

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