A Study Exploring Whooping Cough Protection in Children and Adults

Inclusion Criteria: * Normal general health * Within the right age group for the cohort * Received all regular vaccines for their age group according to the Dutch NIP, UK NIP or Finnish NIP; a copy of the vaccination booklet will be included in the participant's documents. If booklet is not available for cohorts A, B and C, vaccination status will be checked although, for cohort C and D this booklet might not be available due to their age; * Provision of written informed consent * Willing to adhere to the protocol and be available during the study period. Exclusion Criteria: * Present evidence of serious disease(s) within the last 3 months before inclusion requiring immunosuppressive or immune modulating medical treatment, such as systemic corticosteroids, that might interfere with the results of the study; * Chronic infection * Known or suspected immune deficiency; * History of any neurologic disorder, including epilepsy; * Previous administration of serum products (including immunoglobulins) within 6 months before vaccination and blood sampling; * Known and/or suspected allergy to any of the vaccine components (by medical history); * Occurrence of a serious adverse events (SAEs) after primary DTwP-IPV vaccination, DTaP-IPV vaccination or any other vaccination (by medical history); * Vaccination with any other pertussis vaccine other than those described in the inclusion criteria (i.e. only according to NIP) * Vaccination with any other DT-IPV vaccine in the last 5 years, a DT-IPV vaccination according to NIP in cohort B is not an exclusion criterion; * Children between 8 and 10 years of age eligible for cohort A in the Netherlands who have already received the diphtheria and tetanus toxoid vaccine (DT)-IPV booster vaccination according to Dutch NIP around 9 years of age; * Mixed wP and aP priming within a participant, cohort B; * Pregnancy. Detailed considerations for this exclusion criteria in section 4.6. Temporary exclusion criteria * If a participant has a severe acute (infectious) illness or fever (\>38°C) within 14 days prior to T0, participation will be postponed or cancelled. In case the participant has fever within 2 days before sampling at T4 or T5, the appointment will be postponed for 4 days, if possible. * Antibiotic use within 14 days of enrolment. * Any vaccination within a month before enrolment.