Itopride in Feeding Intolerance of Critically-ill Patients Receiving Enteral Nutrition

Inclusion Criteria: * Patients aging between 18 and 60 years (of both sexes) who are admitted to the ICU and are expected to stay in the ICU for not less than 7 days and are prescribed enteral feeding through naso- or oro-gastric tube whose modified nutritional risk in the critically ill (mNUTRIC) score is of more than or equal 5. Exclusion Criteria: * Patients who met the following criteria were excluded: * Age less than 18 years or more than 60 years. * Previous upper gastrointestinal tract surgery, obstruction, hemorrhage or history of GI disease. * Clinically significant hepatic dysfunction. (\>3 times above the upper end of normal range of bilirubin, γ-glutamyl transferase, aspartate transaminase, or lactate dehydrogenase) * Regular use of H2 blockers, prokinetic, proton pump inhibitor or anticholinergic agents for previous 4 weeks. * Patients with arrhythmia or atrioventricular blocks. * Any condition or comorbid disease that might interfere with gastric emptying such as diabetes. * Patients with head injuries.