This study will investigate the safety and interaction of BMS-986177 in healthy volunteers, when administered with Aspirin and/or Clopidogrel
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
113
PPD Development, LP
Austin, Texas, United States
Incidence of Adverse Events (AEs)
Time frame: Up to Day 33
Incidence of Serious Adverse Events (SAEs)
Time frame: Up to Day 95
Incidence of Adverse Events (AEs) leading to discontinuation
Time frame: Up to Day 33
Number of participants with vital sign abnormalities
Time frame: Up to Day 33
Number of participants with 12-lead electrocardiogram (ECG) abnormalities
Time frame: Up to Day 33
Number of participants with clinical laboratory abnormalities
Time frame: Up to Day 33
Number of participants with physical examination abnormalities
Time frame: Up to Day 33
Maximum observed plasma concentration (Cmax)
Cmax of BMS-986177, acetylsalicylic acid, salicylic acid, clopidogrel and clopidogrel metabolite
Time frame: Up to Day 33
Area under the plasma concentration time curve in one dosing interval [AUC(TAU)]
AUC(TAU) of BMS-986177, acetylsalicylic acid, salicylic acid, clopidogrel and clopidogrel metabolite
Time frame: Up to Day 33
Time of maximum observed concentration (Tmax)
Tmax of BMS-986177, acetylsalicylic acid, salicylic acid, clopidogrel and clopidogrel metabolite
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Aspirin tablet
Time frame: Up to Day 33
Terminal plasma half-life (T-HALF)
T-Half of BMS-986177, acetylsalicylic acid, salicylic acid, clopidogrel and clopidogrel metabolite
Time frame: Up to Day 33
Trough observed plasma concentration (Ctrough)
Ctrough of BMS-986177, acetylsalicylic acid, salicylic acid, clopidogrel and clopidogrel metabolite
Time frame: Up to Day 26
Apparent total body clearance (CLT/F)
CLT/F of BMS-986177, aspirin, clopidogrel
Time frame: Up to Day 33
Volume of distribution (Vz/F)
Vz/F of BMS-986177, aspirin, clopidogrel
Time frame: Up to Day 33