The aim of this study was to determine whether changes in serum levels of syndecan-1 before and after surgery, which is an index related to injury of the endothelial glycocalyx layer, are associated with postoperative short-term complications and mortality in patients undergoing robotic esophagectomy.
Study Type
OBSERVATIONAL
Enrollment
221
Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine
Seoul, South Korea
base blood concentration of syndecan-1
preoperative baseline serum levels of syndecan-1
Time frame: within 1 hour before surgery
blood concentration of syndecan-1 at the end of the surgery
blood concentration of syndecan-1 at the end of the surgery
Time frame: within 5 minutes after the end of surgery (when thd surgical drape is removed)
blood concentration of syndecan-1 at 24 hours after surgery
blood concentration of syndecan-1 at 24 hours after surgery
Time frame: 24 hours after the end of surgery
Unanticipated Post-Operative Invasive Procedure (STS GTSD 2.41 #3330)
Indicate if the patient had an unplanned invasive procedure after surgery. Examples includes return to the operating room for a redo surgical procedure, a percutaneous procedure performed at bedside or in the radiology suite, a tracheostomy, and wound opening at bedside. Exclusions: postoperative toilet bronchoscopy, central venous access, arterial line placement, foley catheter placement.
Time frame: during this 1 day hospital visit.
Anastomotic leak following esophageal surgery(STS GTSD 2.41 #3350)
Indicate if the patient had an anastomotic leak following esophageal surgery.
Time frame: within 30days after end of surgery
Respiratory Failure(STS GTSD 2.41 #3480)
Indicate whether the patient experienced respiratory failure in the postoperative period requiring mechanical ventilation and/or reintubation.
Time frame: within 30days after end of surgery
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initial ventilatory support greater than 48 hours (STS GTSD 2.41 #3520)
Indicate if the patient initially was ventilated greater than 48 hours in the postoperative period. If the patient is reintubated, select the postoperative event "Respiratory Failure" and do not select this element even if the reintubation ventilator support is \> 48 hours. Ventilator support ends with the removal of the endotracheal tube or if the patient has a tracheostomy tube, until no longer ventilator dependent.
Time frame: within 30days after end of surgery
pneumonia (STS GTSD 2.41 #3460)
Indicate if the patient experienced pneumonia in the postoperative period. Pneumonia is defined as meeting three of five characteristics: fever (\> 100.4 F or 38 C), leukocytosis, CXR with infiltrate, positive culture from sputum, or treatment with antibiotics.
Time frame: within 30days after end of surgery
renal failure(STS GTSD 2.41 #3810)
Indicate whether the patient had acute renal failure or worsening renal function resulting in any of the following: 1. New requirement for dialysis post-operatively 2. Increase in serum creatinine level 3.0 x greater than baseline 3. serum creatinine level ≥4 mg/dL , with an acute rise of at least 0.5 mg/dl
Time frame: within 30days after end of surgery
mortality(Status 30 Days after Surgery, STS GTSD 2.41 #3950)
Indicate whether the patient was alive or dead at 30 days post-surgery (whether in the hospital or not). time frame: 30days post-surgery
Time frame: 30days post-surgery
Acute kidney injury
defined as an absolute increase in serum creatinine level C0.3 mg/dL, a 50% (1.5-fold) increase in serum creatinine level from baseline, or a reduction in urine output (documented oliguria\< 0.5 mL/kg/h for 6h)
Time frame: within 48 h after end of surgery