Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery

The Institute of Molecular and Translational Medicine, Czech Republic125 enrolled

Overview

To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery. To find correlations with other perioperative factors and clinical/pathological disease characteristics.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

125

Conditions

Colorectal Cancer Circulating Tumor Cell

Interventions

MorphineDRUG

Morphine intravenous

PiritramidDRUG

Piritramid intravenous

EpiduralDRUG

Perioperative epidural analgesia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing open radical surgery for colorectal cancer * age over 18 years * signed informed consent Exclusion Criteria: * intolerance of the study drugs * history of CRC surgery * neoadjuvant therapy * contraindications to epidural analgesia * other malignancy not in permanent remission * chronic opioid medication or opioid administration within 7 days preoperatively * immunosuppressive or corticosteroid therapy * surgery within 30 days preoperatively (except minor) * chronic or acute infection

Locations (3)

T. Bata Regional Hospital Zlin

Zlin, South Moravian, Czechia

University Hospital Ostrava

Ostrava, Czechia

General University Hospital

Prague, Czechia

Outcomes

Primary Outcomes

Change in number of circulating tumor cells prior to surgery to 2 - 4 weeks after surgery

Baseline number of circulating tumor cells will be recorded prior to surgery in a venous blood sample. Number of circulating tumor cells will be measured 2 - 4 weeks after surgery in a venous blood sample. These two values will be compared.

Time frame: 1 - 3 days before surgery to 4 weeks after surgery

Secondary Outcomes

Pain assessment

Pain intensity assessed using Numerical Rating Scale (0-10)

Time frame: 3 days postoperatively

Data from ClinicalTrials.gov

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