Using a prospective cohort of children admitted to the PICU, the investigators will determine HRV monitoring is feasible, if a decreased HRV in the 7 days following moderate or severe TBI in children is associated with a worse outcome 6 months post-TBI and investigate HRV as a tool that can predict adverse events (neurological crisis) within 2 days following TBI.
This is a single center prospective cohort study of 15 children \<18 years, admitted to the PICU at the CHU Sainte-Justine (CHUSJ) with moderate or severe TBI (\<24 hours). Neurodevelopment outcome of children will be evaluated 6 months post TBI.
Study Type
OBSERVATIONAL
Enrollment
15
HRV monitoring derived from electrocardiogram
CHU Sainte-Justine
Montreal, Quebec, Canada
% of the time with reliable HRVmonitoring in children with TBI
Feasibility of having a reliable capture and analysis of HRV 7 days post TBI
Time frame: 1 year
Rate of adverse events preceded by a decreased HRV
Adverse events will be defined as increased intracranial pressure, decreased CPP, seizure and cardiac arrest
Time frame: 1 year
HRV and neurological outcome
The primary outcome of neurological and functional outcome will be assessed by the Pediatric Glasgow Outcome Scale Extended (P-GOSE) 6 months post TBI. P-GOSE is an 8-point ordinal scale (1= best outcome) The score will be classified as favourable (P-GOSE 1 or 2, or decreased of P-GOSE of 1 point post PICU (∆ P-GOSE ≤1) or unfavourable (P-GOSE ≥3 or ∆ P-GOSE ≥2)
Time frame: 1.5 year
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