Victor2 is an observational cohort study over two years and is designed to investigate longitudinal changes of visual impairment in multiple sclerosis (MS). The investigators aim to recruit patients in the relapsing-remitting phase of the disease (n=50) as well as progressive MS patients (n=50). Both cohorts will be compared with age and gender matched healthy controls (HC). All participants undergo yearly clinical assessments including standard charts for visual acuity (Sloan, Snellen), a new computer adaptive test measuring the complete contrast sensitive function (CSF), optical coherence tomography and a vision related quality of life questionnaire (NEI-VFQ). The study aims to validate and extend previous finding from a cross-sectional study which found a better association between CSF and NEI-VFQ than for standard charts. Moreover, the study is designed to proof also a better association with anterior visual system integrity as assessed with OCT.
Study Type
OBSERVATIONAL
Enrollment
200
Institute of Neuroimmunology and MS
Hamburg, Germany
RECRUITINGCorrelation between ganglion cell / inner plexiform layer (GCIPL) thickness loss and area under the log CSF curve change over two years
GCIPL thickness represents anterior visual system integrity on neuronal level and its change over two years will be correlated with the change of the CSF
Time frame: 2 years
Correlation between retinal nerve fibre layer (RNFL) thickness loss and area under the log CSF curve change over two years
To correlate anterior visual system integrity with contrast vision assessed with the CSF
Time frame: 2 years
Longitudinal correlation between visual quality of life and contrast vision
To correlate Quality of life scores from the national eye institute visual functioning questionnaire questionnaire with contrast vision assessed with the CSF
Time frame: 2 years
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