Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

N/AUnknownNCT03703973

Xuzhou Medical University1,000 enrolled

Overview

To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Postoperative Cognitive Dysfunction

Interventions

Neuropsychology testDIAGNOSTIC_TEST

We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.

Eligibility

Sex: ALLMin age: 60 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Non-cardiac surgery patients; * Age is greater than or equal to 65 years old; * Han Nationality, mother tongue is chinese; ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; ⑤The Geriatric Depression Scale (GDS) grade 1 or 2; ⑥The important function without serious heart, brain, liver, kidney, lung and other organs; * The ASA class I or II; * The people signed informed consent. Exclusion Criteria: * The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery; * Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.

Locations (1)

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

RECRUITING