Food Modification to Alter Glycaemia and Insulinaemia

Singapore Institute of Food and Biotechnology Innovation14 enrolled

Overview

The study specifically aims to determine glycemic and insulinemic response of added low GI ingredients, beta-glucan, resistant starch and isomaltulose to foods.

There will be a total of 9 test sessions and each session will last up to 3 hours. At each test session, the following procedures will be performed: two finger-prick blood samples, five minutes apart to measure baseline blood glucose and insulin concentrations. Subject will be served the test food and to consume within15 minutes. Following the test meal, blood samples will be collected at the following time points: 15, 30, 45, 60, 90, 120, 150 and 180min for glucose measurements and insulin measurements will be collected at 30, 60, 90, 120, 150 and 180min.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Diabetes

Interventions

Glucose Reference 1OTHER

Glucose contains 50g of available carbohydrates

Glucose Reference 2OTHER

Glucose contains 50g of available carbohydrates

Glucose Reference 3OTHER

Glucose contains 50g of available carbohydrates

Eligibility

Sex: MALEMin age: 21 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy Males * Chinese ethnicity * Age ≥21 and ≤ 40 years * Body mass index between 18.5 to 25 kg/m2 * Normal blood pressure ≤140/90 mmHg * Fasting blood glucose \<6.0 mmol/L * In general good health Exclusion Criteria: * Current smoker * Have metabolic diseases (such as diabetes, hypertension etc) * Have glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) * Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics) * Have an ongoing infection or currently undergoing treatment at the time of screening * Have known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV) * Have active Tuberculosis (TB) or currently receiving treatment for TB * Intolerances or allergies to any foods * Partake in sports at the competitive and/or endurance levels * Intentionally restrict food intake

Locations (1)

Clinical Nutrition Research Centre

Singapore, Singapore

Outcomes

Primary Outcomes

Glucose

Blood glucose will be collected using finger prick method and analysed using Hemocue analyser

Time frame: up to 180 minutes

Insulin

Blood glucose will be collected using finger prick method and analysed using Cobas analyser

Time frame: up to 180 minutes

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.