Boost Brittle Bones Before Birth

Inclusion Criteria Postnatal Group: 1. Parent's/legal guardian's signed informed-consent form 2. Clinical diagnosis of OI type III or severe type IV AND 3. Molecular diagnosis of OI (Glycine substitution in the collagen triple-helix encoding region of either the COL1A1 or COL1A2 gene) 4. Age less than 18 months (calculated from gestational week 40+0, i.e. the corrected age) 5. Parent/legal guardian over 18 years of age Inclusion Criteria Prenatal Group: 1. Woman has signed the informed-consent form 2. Only women where termination of the pregnancy is no longer possible or where the women are committed to continue the pregnancy may be included in the trial 3. Suspicion of OI type III or severe type IV in the fetus on ultrasound findings AND 4. Molecular diagnosis of OI in the fetus (Glycine substitution in the collagen triple-helix encoding region of either the COL1A1 or COL1A2 gene) 5. Gestation age between 16+0 and 35+6 weeks+days 6. Pregnant woman over 18 years of age Inclusion Criteria Historical Control Group: 1. Parent's/legal guardian's signed informed-consent form 2. Clinical and molecular diagnosis of OI (Glycine substitution in the collagen triple-helix encoding region of either the COL1A1 or COL1A2 gene) 3. Data on fractures and growth is available 4. Parent/legal guardian over 18 years of age Inclusion Criteria Prospective Untreated Control Group: * Postnatal inclusion: The inclusion criteria for the postnatal group apply. * Prenatal inclusion: The inclusion criteria for the prenatal group apply, except inclusion criteria 2. Exclusion Criteria Postnatal Group: 1. Existence of other known disorder that might interfere with the treatment, such as, but not limited to organ dysfunction (for example liver or renal failure or bronchopulmonary dysplasia), congenital heart defect, hypoxic encephalopathy l-lll, severe neurological problems, immune deficiencies, muscle diseases, severe malformations or syndromes diagnosed by clinical examination. 2. Any contraindication for invasive procedures such as a moderate/severe bleeding tendency 3. Known risk factors for clotting, such as, but not limited to previous blood clot, family history of clots, clotting disorder (inherited or acquired), heart failure, inflammatory disorders (for example lupus, rheumatoid arthritis, inflammatory bowel disease) 4. Positive Donor Specific Antibody-test 5. Known allergy/hypersensitivity to Fungizone and/or Gensumycin 6. Abnormal karyotype or other confirmed genetic syndromes 7. Oncologic disease (previous or current malignancy) 8. Inability to comply with the trial protocol and follow-up schedule 9. Inability to understand the information and to provide informed consent Exclusion Criteria Prenatal Group: 1. Multiple pregnancy 2. Co-existence of other disorder that might interfere with the treatment, as judged by the Investigator or the patient's obstetrician 3. Abnormal fetal karyotype or other confirmed genetic syndrome 4. Any contraindication for invasive procedures such as a bleeding tendency or contagious infections, such as, but not limited to HIV, Syphilis, Hepatitis B, Hepatitis C or other known infectious diseases that can harm the fetus 5. Known risk factors for clotting, such as, but not limited to previous blood clot, family history of clots, clotting disorder (inherited or acquired), heart failure, inflammatory disorders (for example lupus, rheumatoid arthritis, inflammatory bowel disease) 6. Positive Donor Specific Antibody-test 7. Known allergy/hypersensitivity to Fungizone and/or Gensumycin 8. Oncologic disease in woman or fetus (previous or current malignancy) 9. Unwilling to or cannot undergo delivery by elective Caesarean section 10. Inability to comply with the trial protocol and follow-up schedule 11. Inability to understand the information and to provide informed consent Exclusion Criteria Historical Control Group: 1. Existence of other disorder that might interfere with the trial. No lung hypoplasia (type II OI). 2. Abnormal karyotype Exclusion Criteria Prospective Untreated Control Group: * Postnatal inclusion: The exclusion criteria, except exclusion criterium 2, 3, 4 and 5 (Contraindication for invasive procedure, Known risk factor for clotting, Positive Donor Specific Antibody-test and Known allergy/hypersensitivity to Fungizone and/or Gensumycin) for the postnatal group apply. * Prenatal inclusion: The exclusion criteria, except exclusion criterium 1, 4, 5, 6 and 7 (Multiple pregnancy, Contraindication for invasive procedure, Known risk factor for clotting, Positive Donor Specific Antibody-test and Known allergy/hypersensitivity to Fungizone and/or Gensumycin) for the prenatal group apply.