A Safety and Efficacy Study of Intranasal GSK2245035 in Adults With Allergic Asthma

Inclusion Criteria: * Between 18 and 65 years of age inclusive, at the time of signing the informed consent. * Physician confirmed diagnosis of asthma for at least 6 months prior to screening. * Asthma therapy with inhaled corticosteroids (fluticasone propionate dry powder inhaler \[FP-DPI\] \>=100 micrograms (mcg), or equivalent, total daily dose) \>=3 months (at time screening visit 1 \[SV1\]). * Body weight \>= 45 kilograms (kg). * Male or female of non-reproductive potential. A male subject must agree to use a highly effective contraception during the treatment period and at least from the time of first dose of study medication until the final follow-up visit and refrain from donating sperm during this period. A female subject is eligible to participate if she is not a woman of childbearing potential (WOCBP). * Capable of giving signed informed consent. Exclusion Criteria: * Current smokers or former smokers with a smoking history \>=10 pack years. * Clinically significant abnormal laboratory result (Chemistry, Hematology and Urinalysis) at SV1. * Alanine transaminase (ALT) \>2xupper limit of normal (ULN) and bilirubin \>1.5xULN (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35 percent). * Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones). * Clinically significant and abnormal electrocardiogram (ECG) at screening visit 1. * Heart rate corrected QT interval (QTc) \> 450 milliseconds (msec) or QTc \> 480 msec in subject with Bundle Branch Block. * Subjects with a diagnosis of malignancy or in the process of investigation for a malignancy. * Subjects on oral corticosteroid therapy. * Subjects who have received treatment with allergen immunotherapy (in the last 2 years), anti-immunoglobulin E (IgE) or anti interleukin 5 (IL5) or anti IL13 antibodies or immunosuppressive agents (example given \[e.g.\] methotrexate, azothioprine, cyclosporine) within the past 6 months. * A pre-bronchodilator forced expiratory volume in 1 second (FEV1) \< 50 percent predicted of normal value. * Occupational asthma due to low molecular weight chemicals. * Asthma exacerbation requiring treatment with systemic corticosteroids or hospitalization within 3 months prior to screening. * History of life-threatening asthma, defined as an asthma episode that required intubation and/or was associated with hypercapnia, respiratory arrest or hypoxic seizures within the last 10 years. * Evidence of concurrent respiratory diseases such as pneumonia, tuberculosis, pneumothorax, atelectasis, pulmonary fibrotic disease, allergic bronchopulmonary aspergillosis, cystic fibrosis, bronchopulmonary dysplasia, or other respiratory abnormalities other than asthma. * Respiratory tract infection that is not resolved within 2 weeks prior to screening. * Other conditions that could lead to elevated eosinophils such as hypereosinophilic syndromes. Subjects with a known, pre-existing parasitic infestation within 6 months prior to screening. * A current or past diagnosis of an autoimmune disorder such as systemic lupus erythematosus (SLE). * Other concurrent diseases/abnormalities: A subject must not have any clinically significant uncontrolled condition, or disease state, that, in the opinion of the investigator, would put the safety of the subject at risk through study participation. E.g. Addison's disease hypertension 1 (uncontrolled) aortic aneurysm (clinically significant), peptic ulcer (recent or poorly controlled), Cushing's disease, renal disease, diabetes mellitus (uncontrolled), stroke within 3 months of screening visit 1, thyroid disorder (uncontrolled), hepatic disease tuberculosis (current or untreated). * History of sensitivity to any of the study medications, including Albuterol/Salbutamol or Albuterol components there of or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation. * History of hypersensitivity to investigational medicinal product (IMP) or to drugs of similar chemical class (TLR agonists). * The subject has received an investigational medicinal product within 30 days or, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer). Use of a biologic (e.g. monoclonal antibodies) agent for the treatment of asthma in the past 6 months. * Exposure to more than 4 investigational medicinal products within 12 months prior to the first dosing day. * Presence of hepatitis B surface antigen (HbsAg), positive hepatitis C antibody test result at screening or within 3 months prior to first dose of study treatment. * Known positive for Human Immunodeficiency Virus (HIV) antibody. * Donation or loss of 400 milliliters (mL) or more of blood within 8 weeks prior to initial dosing, or longer if required by local regulation or hemoglobin levels below normal range at screening or where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period. * History of regular alcohol consumption within 6 months of the study defined as: An average weekly intake of \>14 units for males and females. One unit is equivalent to 8 grams (g) of alcohol: a half-pint (approximately 240 mL) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits. * A history of substance abuse including alcohol. * Subjects at risk of non-compliance, or unable to comply with the study procedures. * Subjects who are unable to follow study instructions such as visit schedule, dosing directions, study electronic diary (eDiary) completion, or use of a standard metered dose inhaler. Any infirmity, disability, or geographic location that would limit compliance for scheduled visits.