This pilot study will examine the effect of a mobile health text messaging platform linked to a digital physical activity tracker on physical activity among persons living with HIV and frailty.
HIV is associated with frailty, an important aging-related phenotype associated with adverse clinical outcomes. The investigators propose that personalized health coaching using a digital activity tracker with mobile health text messaging can increase physical activity in this population. The total duration of the intervention will be 12 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
20
Group wears physical activity tracker and receives physical activity feedback information informed by the tracker
Group receives personalized, health coaching via "smart" text messages
Group receives baseline counseling on physical activity
Johns Hopkins University
Baltimore, Maryland, United States
Change in Mean daily step count
Mean daily step count will be assessed using a digital physical activity tracker
Time frame: Baseline, 12 weeks
Change in Frailty as assessed by the Fried-based physical frailty phenotype
Frailty evaluated based on the standard 5 point Fried-based frailty phenotype construct (slow gait, weakness, weight loss, exhaustion, low physical activity)
Time frame: Baseline, 12 weeks
Change in Physical Fitness as assessed by 12 minute walk
Physical fitness of participants will be assessed by the ability to do a 12 minute walk
Time frame: Baseline, 12 weeks
Change in Muscle strength as assessed by isokinetic resistance
Muscle strength evaluated using isokinetic resistance testing on a Biodex system measuring peak torque expressed as foot pounds (lbs)
Time frame: Baseline, 12 weeks
Percent change in fat mass
Fat mass will be measured using the dual-energy x-ray absorptiometry (DXA) scan
Time frame: Baseline, 12 weeks
Percent change in lean mass
Lean mass will be measured using the dual-energy x-ray absorptiometry (DXA) scan
Time frame: Baseline, 12 weeks
Change in Physical performance as assessed by the physical performance battery
Physical performance evaluated with the short physical performance battery
Time frame: Baseline, 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Change in Quality of Life as assessed by the Medical Outcomes Study HIV Health Survey (MOS-HIV)
The Medical Outcomes Study HIV Health Survey (MOS-HIV) is a brief, comprehensive measure of health-related quality of life. The 35-item questionnaire includes 10 dimensions (pain, physical, role, health perceptions, social and cognitive functioning, energy, mental health, health distress and quality of life). Each dimension is scored on a 0-100 scale (a higher score indicates better health related quality of life). An overall score is obtained through a summation of z scores from each domain.
Time frame: Baseline, 12 weeks
Change in Interleukin-6 (IL-6) concentration
Interleukin-6 concentration in pg/ml will be measured at baseline and be compared to the concentration at 12 weeks to assess any change
Time frame: Baseline, 12 weeks
Change in soluble Tumor Necrosis Factor Receptor 1 (sTNFR1)
sTNFR1 concentration in ng/ml will be measured at baseline and be compared to the concentration at 12 weeks to assess any change
Time frame: Baseline, 12 weeks