In the present study, consecutive patients, older than 18 years, of both genders will be included. The diagnosis of reduced Heart Failure (HfrEF) according to: Clinical pattern, laboratories and Cardiac imaging (ESC criteria). Treatment will be assigned in two groups: Bumetanide and another group will be received Indapamide. Each group received maximum tolerated dose for seven days with Clinical and labs evaluations will be every 48 hrs. (Face-to-face and/or telephone visits). Serum and urinary labs, EKG´s, Echo will be evaluated. Daily in-home register will made. Final points were: Mortality, Urinary failure, Clinical Impairment, Hospital admissions, Oedema. (MUCHO). All patients will be followed for 30 days.
In selected patients who sign informed consent with decompensation of cardiac failure by water congestion will be allocated in two groups: Bumetanide and the other Indapamide group. Each group will be given the maximum tolerated dose for seven days with clinical evaluations every 48 hours. (Face to face and/or telephone). Clinical variables, ECG and serum and urine laboratories will be assessed finally, patients will follow up for 30 days. To identify endpoints such as: mortality, urinary failure, clinical deterioration, hospital admissions, edema. (MUCHO).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
all patients will be taking the treatment recommended by heart failure guidelines
Centro de Insuficiencia Cardiaca Instituto Nacional de Cardiologia
Mexico City, Mexico
RECRUITINGMORTALITY
HEART FAILURE DEATH, CARDIOVASCULAR DEATH, OTHER DEATH
Time frame: 30 DAY
REHOSPITALIZATION
HEART FAILURE REHOSPITALIZATION, CARDIOVASCULAR REHOSPITALIZATION, OTHER REHOSPITALIZATION
Time frame: 30 DAY
URINARY FAILURE
RENAL DETERIORATION (GFR \< 50%)
Time frame: 30 DAY
CLINICAL IMPAIRMENT
FUNCTIONAL CLASS DETERIORATION
Time frame: 30 DAY
OEDEMA
ABNORMAL ACCUMULATION OF FLUID (SWOLLEN ANKLE)
Time frame: 30 DAY
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.