The purpose of this study is to understand the effect of vascular endothelial growth factor tyrosine kinase (VEGF) inhibitor, immune checkpoint-inhibitor (ICI), and combination treatment on blood pressure and blood vessel function.
Study Type
OBSERVATIONAL
Enrollment
2
Baseline: Subjects will undergo an abbreviated physical exam, review changes in medical history since last oncology visit, blood collection, urine collection, blood pressure and heart rate in triplicate, baseline and hyperemic digital velocity time interval (VTI) using pulse amplitude tonometry, cubital vein endothelial cell harvest, and ambulatory 24 blood pressure measurement. Follow-up Visit (approx 1 month after starting treatment): Review changes in medications and any medical events that happened since the last visit, an abbreviated physical exam, blood collection, urine collection, blood pressure and heart rate in triplicate, baseline and hyperemic velocity time interval (VTI), digital pulse amplitude tonometry, endothelial cell harvest, and ambulatory 24 blood pressure.
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Change in Mean Blood Pressure
Mean 24 hour blood pressure from ambulatory 24 hour recording
Time frame: Baseline and 1 month
Ratio of Post-treatment to Pre-treatment Change in Digital Pulse Amplitude
Digital pulse amplitude will be measured using peripheral artery tonometry
Time frame: Baseline and 1 month
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