4-way Crossover QT Evaluation in Healthy Subjects

Inclusion Criteria: * physically and mentally healthy volunteer * a man or woman, 18 to 55 years of age * a woman of childbearing potential using birth control / negative pregnancy test or a woman of non-childbearing potential * males with female partners of childbearing potential agree to use contraception * body mass index 19.0 to 32.0 kg/m2; weight of at least 60.0 kg at Screening * willing to complete the required 4 study periods Exclusion Criteria: * History or evidence of cerebrovascular or cardiac disease * Uncontrolled hypertension * Electrographically significant abnormalities on ECG * Clinically significant medical history (PI assessment) * Clinically relevant lab abnormalities (PI assessment) * Calculated eGFR \< 60.0 mL/min/1.73m2 based on CKD-EPI 2009 equation * Abnormal liver tests * Positive serology HIV, HBsAg, or Hep C virus * Hemoglobin, hematocrit, electrolytes below lower limit of normal * Received any hepatic or renal clearance altering agents within 30 days * History of allergy or hypersensitivity to drugs with clinically significant reaction * Unwilling to refrain from strenuous exercise from 7 days prior to admission until discharge * Uses any prescription drug / OTC, within 7 days prior to admission, or 14 days prior to Admission if the drug is a potential inducer or inhibitor of cP450, or 5 half-lives (if longer), or subject continued use of a prescription drug / OTC medication (except contraceptives) * Scheduled to have surgical procedure during study * Acute illness that has resolved in less than 14 days, or has had a major illness, or hospitalization within 1 month * Unwilling to abstain from ingestion of caffeine or xanthine-containing products 96 hours prior and throughout study * Unwilling to abstain from alcohol beginning 72 hours prior and throughout study * History of high alcohol consumption within 6 months * History of drug abuse (in the previous 3 years) or positive urine drug screen * Used tobacco-containing products within 6 months or has a positive cotinine * Consumed grapefruit and/or grapefruit juice within 14 days and throughout study * Consumed other fruit juices within 72 hours and throughout study * Consumed cruciferous vegetables or charbroiled meats within 7 days and throughout study * Donated plasma or blood within 30 days or has a history of blood donation of \> 450 mL within 3 months * Used any investigational drug within 30 days * Previously received fosfomycin * Deemed by the Investigator to be inappropriate for this study * Participated in another clinical study within 30 days (or 5 half-lives)