Observational Study of Drug Naive Diabetes Receiving Insulin Therapy

Inclusion Criteria: for type 2 diabetes: 1. Male or female age ≧ 25 years and ≦75 years old 2. HbA1c ≧8.0% 3. durg naive for normal controls： 1. Male or female age ≧ 25 years and ≦75 years old 2. Normal glucose tolerance confirmed by oral glucose tolerance test Exclusion Criteria: 1. Islet antibody positive 2. Athletes, has a history of skeletal muscle injury ( trauma or surgery ), skeletal muscle wasting diseases ( such as mitochondrial myopathy, muscular atrophy, etc ) 3. Acute infection(such as cute upper respiratory infection, acute pneumonia) 4. long-term use of non-steroidal anti-inflammatory drugs, corticosteroids and immunosuppressive drugs 5. consists with other endocrine diseases 6. pregnancy 7. cancer 8. use of antibiotics in 3 months 9. chronic digestive inflammations 10. magnetic resonance imaging contraindications