Inulin and Acetate Production and Human Substrate Metabolism

Maastricht University Medical Center24 enrolled

Overview

Based on our hypothesis that orally administered resistant starch and inulin/beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To investigate the effects of an acute administration of inulin/beta glucan in combination with resistant starch on fecal and plasma acetate, as well as on fasting and postprandial substrate and energy metabolism in lean normoglycemic men and obese, prediabetic men.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Obesity Pre Diabetes

Interventions

Inulin and Resistant StarchDIETARY_SUPPLEMENT

12g per inulin in combination 7.5 g resistant starch per day the day before the CID Resistant starch 7.5 g

InulinDIETARY_SUPPLEMENT

12g per inulin in combination with maltodextrin per day the day before the CID

PlaceboDIETARY_SUPPLEMENT

isocaloric maltodextrin before test day

Eligibility

Sex: MALEMin age: 30 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * lean (BMI ≥ 20kg/m2 and ≤ 24.9kg/m2) * normoglycemic * aged 30 - 65 years OR * overweight/obese (BMI ≥ 25kg/m2 and ≤ 34.9kg/m2) * pre-diabetes * aged between 30 - 65 years. Exclusion Criteria: * diabetes mellitus * gastroenterological diseases or major abdominal surgery (allowed i.e.: - appendectomy, cholecystectomy) * lactose intolerance and other digestive disorders * cardiovascular disease, cancer, liver or kidney malfunction (determined -based on ALAT and creatinine levels, respectively) * disease with a life expectancy shorter than 5 years * Use of antibiotics 3 months prior inclusion * Use of probiotics or prebiotics

Locations (1)

Maastricht University Medical Centre

Maastricht, Netherlands