Compassionate Use Study of Tenalisib (RP6530)

Inclusion Criteria: 1. Patients must be currently receiving treatment with Tenalisib on a previously approved protocol. 2. Patients must have had at least one efficacy evaluation in previous study and should have achieved either SD, PR or CR. 3. Patients must have completed at least 6 cycles of Tenalisib in previous study 4. Ability to swallow and retain oral medication. 5. Female patients of child-bearing potential must consent to use two medically acceptable methods of contraception. 6. Male patients must be willing to use adequate contraceptive measures 7. Willingness and ability to comply with trial and follow-up procedures. 8. Willingness to provide new written informed consent. Exclusion Criteria: 1. Patient has been discontinued from their previous Tenalisib study 4 weeks prior to entering the compassionate use trial. 2. Patient progressed while receiving Tenalisib therapy in his/her previous study. 3. Pregnant or lactating woman. 4. Inability or unwillingness to comply with study and/or follow-up procedures outlined in the protocol. 5. Concurrent condition that in the investigator's opinion would jeopardize compliance with the protocol.