Effects of Dapagliflozin+Saxagliptin in Addition to Metformin v/s Saxagliptin or Dapagliflozin in Patients With DM2.

Inclusion Criteria: 1. Males and females 2. Age = 35-70 years 3. BMI ≤ 40 Kg/m 2 and stable weight (± 3 lbs) over the preceding three months 4. Type 2 diabetes (HbA1c \> 7 % and \< 10 %) 5. Metformin on stable dose (at least 1500 mg/day) for at least 12 weeks before screening and at study initiation. 6. Subjects who are women of childbearing potential must agree to utilize a highly effective contraceptive measure throughout the course of the study.. 7.7. Subjects are capable of giving informed consent Exclusion Criteria: 1. Drugs known to affect glucose metabolism (other than metformin) for more than14 days during the 12 weeks before screening 2. Known Dapagliflozin and Saxagliptin Excipient Hypersensitivity 3. Type 1 Diabetes or History of Ketoacidosis 4. history of cancer of any type; 5. cerebrovascular or symptomatic peripheral vascular disease; 6. heart disease class III or IV NYHA; 7. Estimated glomerular filtration rate (eGFR) ≤60 mL/min/1.73m 2 or serum creatinine \> 1.5mg/dL in men or \>1.4mg/dL in women 8. Liver function enzymes higher more than two times the upper limit 9. Ongoing urinary tract infection 10. drug or alcohol abuse; 11. life expectancy \<3 yrs 12. blood pressure \>160/100 mmHg 13. Donation of blood to a blood bank, blood transfusion, or participation in a clinical study requiring withdrawal of \> 400 mL of blood during the 8 weeks prior to the enrollment visit and at least 8 weeks thereafter 14. Women of child bearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study (estrogen and/or progesterone treatment) 15. Women who are pregnant or breastfeeding 16. Patient with a history or current evidence of any condition, therapy, laboratory abnormality, or other circumstance which, in the opinion of the investigator or coordinator, might pose an unacceptable risk to the patient or interfere with trial procedures