Based on our hypothesis that orally administered resistant starch and beta glucan will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To investigate the effects of an acute administration of inulin/beta glucan in combination with resistant starch on fecal and plasma acetate, as well as on fasting and postprandial substrate and energy metabolism in lean normoglycemic men and obese, prediabetic men.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
24
12g per day the day before the CID Resistant starch 7.5 g
isocaloric maltodextrin before the CID
12 g beta gluten there day before the CID
Maastricht University
Maastricht, Limburg, Netherlands
Plasma acetate concentrations (microM)
Time frame: at baseline (before a high-fat mixed meal)
Plasma acetate concentrations (microM)
Time frame: four hours after a high fat mixed meal
Energy expenditure (kJ/min) will be measured using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands)
Time frame: at baseline and four hours after a high fat mixed meal
fat oxidation (g/min) will be measured using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands)
Time frame: at baseline and four hours after a high fat mixed meal
carbohydrate oxidation (g/min) will be measured using an open-circuit ventilated hood system (Omnical, Maastricht University, The Netherlands)
Time frame: at baseline and four hours after a high fat mixed meal
Circulating hormone concentrations (Insulin, GLP-1, PYY)
Time frame: at baseline and four hours after a high fat mixed meal
Circulating metabolite concentrations (Glucose, Free Fatty Acids, Triglycerides)
Time frame: at baseline and four hours after a high fat mixed meal
Plasma glucose (mmol/L)
Time frame: at baseline and four hours after a high fat mixed meal
Free Fatty Acids (micromol/L)
Time frame: at baseline and four hours after a high fat mixed meal
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Breath H2 using (Bedfont EC60 Gastrolyzer, Rochester, UK)
Time frame: at baseline and four hours after a high fat mixed meal