The aim of the study is to 1. To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively. 2. To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes 3. To investigate if non-oxidized PTH reflects bone turnover
Patients with reduced renal function and suspected high turnover or low turnover bone disease are recruited. A bone biopsy and a 18F-PET scan are performed and it is investigated if the 18F-PET can discriminate high turnover from low turnover bone disease
Study Type
OBSERVATIONAL
Enrollment
40
Bone biopsy and 18F-PET
Herlev Hospital
Herlev, Denmark
RECRUITINGCan 18F-PET-CT describe bone formation rate?
The ROC curve for 18F uptake by bone measured as bone plasma clearance (ki) to descriminate between high and low bone turnover measured as bone formation rate
Time frame: The bone biopsy and 18F-PET will be performed during two month for each participant
Can non-oxidized PTH describe bone formation rate?
The relation between non-oxidized PTH in ng/L and bone turnover in bone biopsy described as bone formation rate
Time frame: Blood sample and bone biopsy will be performed during two month for each participant
Can 18F-PET-CT describe mineral apposition rate?
The ROC curve for 18F uptake by bone measured as bone plasma clearance (ki) to descriminate between high and low bone turnover measured as mineral apposition rate
Time frame: The bone biopsy and 18F-PET will be performed during two month for each participant
Can non-oxidized PTH describe mineral apposition rate?
The relation between non-oxidized PTH in ng/L and bone turnover in bone biopsy described as mineral apposition rate
Time frame: Blood sample and bone biopsy will be performed during two month for each participant
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