The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Physical activity in children and adults with asthma.
Pediatric Exercise and Genomics Research Center, University of California, Irvine
Irvine, California, United States
Gene and microRNA expression will be compared between healthy and asthmatic subjects
Monocyte gene expression profiling before and after acute bout of exercise before and after 10-week exercise intervention is gauged using RNA seq in a group of children with asthma and age and sex match healthy controls
Time frame: 12 weeks
Pro/anti-inflammatory cytokines and markers of oxidative stress will be compared between the groups
Absolute values of cytokines, growth hormones, and other biomarkers will be measured by flow cytometry and statistically analyzed.
Time frame: 12 weeks
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