Adults older than 18 years old, admitted to the ICU with a Severe Septic Shock, requiring Norepinephrine at more than 0.25mcg/kg/min, who have signed informed consent form, will be consecutively included, from december 2018 to december 2019. The primary goal is to look for risk factors associated with an increased in lactate clearance Secondary goals are the following: 1. To look for risk factors associated with an increase risk of Hospital and ICU length of stay. 2. To look for risk factors associated with an increase risk of Acute Kidney Injury. 3. To look for risk factors associated with a decrease in days alive and free of Mechanical Ventilation, Vasopressors and Renal Replacement Therapy. 4. To look for risk factors associated with a decrease in Ventilator-free days. 5. To look for risk factors associated with a decrease in Vasopressor-free days. 6. To look for risk factors associated with an increase risk of in-hospital mortality. 7. To look for risk factors associated with an increase risk of Myocardial Infarction and myocardial injury. 8. To look for risk factors associated with an increase risk of Acute Respiratory Distress Syndrome. 9. To compare and validate different risk scores in our cohort.
Study Type
OBSERVATIONAL
Enrollment
300
Hospital Universitari Dr Josep Trueta
Girona, Spain
Lactate clearance
Time from hospital arrival to documented serum lactate of less than or equal to 2 mmol/L
Time frame: 30 days
Days alive and free of Mechanical Ventilation, Vasopressors and Renal Replacement Therapy
Number of days from the last day free of vasopressors, mechanical ventilation and Renal Replacement Therapy up to day 28. If patients dies it scores 0.
Time frame: 28 days
Mechanical Ventilation-free days
Days free of mechanical ventilation up to day 28
Time frame: 28 days
Vasopressors-free days
Days free of vasopressors up to day 28
Time frame: 28 days
Rate of Acute Kidney Injury
Kidney Disease: Improving Global Outcomes definition
Time frame: 28 days
ICU length of stay
Days in ICU
Time frame: 28 days
Hospital length of stay
Days in Hospital
Time frame: 30 days
Rate of In-hospital Mortality
Any cause mortality
Time frame: 30 days
Rate of Acute Respiratory Distress Syndrome
Berlin definition
Time frame: 28 days
Rate of New Atrial Fibrilation
New atrial fibrilation requiring treatment
Time frame: 28 days
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