BRAN Pilot Study: Metabolic Signature of Wheat Bran Related to Gut Fermentation in Humans

Inclusion Criteria: * Subject able to understand the information given to him and having signed the informed consent form. * subject having had a medical examination during the selection visit * Healthy subject * Female gender * Age between 20 and 40 years (limits included) * No Smoking * Body mass index between 20 and 25 kg / m2 (limits included). * fiber consumer ≥ 18 g / day * Do not present any food allergy, nor food intolerance to the products of the study. * Having no particular diet (vegetarian, vegan, high protein, etc.) * Having a stool frequency ranging from 1 to 2 per day over the last 2 months * Absence of pathology detectable by clinical examination and medical examination that may interfere with the evaluation criteria of the study. * Sedentary subject or practicing steady regular physical activity during the entire study (maximum 4 hours per week). * Accepting to submit to the protocol of the study with a day of hospitalization of 24h * Stable weight in the last 3 months (+/- 5% of total body weight) * Affiliation to a social security scheme. Exclusion Criteria: General criteria * Subject presenting unstable medical or psychological conditions which, according to the investigator, could lead the subject to be non-compliant or uncooperative during the study or could compromise the safety or participation of the subject under study (according to Articles L.1121-6, L.1121-8, L.1121-9 and L1122-1-2 of the Public Health Code). * Failure to respect the exclusion period of another study specified in the "National Volunteer File". * Major subject under guardianship. * Private subject of his liberty by judicial or administrative decision. * Subject having exceeded the annual amount of compensation for participation in research protocols. * Not having a refrigerator and / or freezer (necessary for the conservation of collections of urine and / or stool made at home) Biological criteria * Total blood cholesterol\> 11 mmol / L or blood triglycerides\> 3 mmol / L * Fasting blood glucose\> 7 mmol / L * CRP\> 10 mg / L * Demonstration of a biological abnormality judged by the investigator to be clinically significant * Transaminases (ASAT and ALAT) and gamma GT greater than 1.5 times the upper limit of normal Medical and therapeutic criteria: * History of bariatric surgery * History of digestive surgery with the exception of appendectomy * Subject presenting gastrointestinal disorders such as ulcers, diverticula or inflammatory bowel diseases * Diabetes type 1 or 2. * Chronic renal failure. * Chronic liver failure. * known gastroparesis, gastrectomy, colectomy. * History of chronic gastrointestinal disease with malabsorption. * External pancreatic insufficiency. * Known endocrine pathology that can interfere with carbohydrate metabolism (uncontrolled dysthyroidism, acromegaly, hypercorticism, ...). * Subject with organic intestinal disease. * subject who has undergone antibiotic therapy in the 3 months preceding the study may interfere with transit or intestinal microbiota: * Subject treated with a drug that may interfere with carbohydrate metabolism: * Corticosteroids. * anorectics. * High dose gastric bandages. * Subject having a concomitant pathology incompatible with the constraints of the protocol or which may interfere with the evaluation of the main criterion. * PA systolic not between 100 and 140 mmHg and diastolic not between 50 and 90 mmHg * Dieting or wishing to lose weight * Pregnant woman or wishing to be pregnant or breastfeeding (interrogation data) * Alcoholism or abuse or dependence on another proven drug. Consumption of more than 3 alcoholic beverages per day is considered abusive. An alcoholic beverage is 30 mL of spirits, 120 mL of wine or 330 mL of beer * Donation of blood in the 2 months preceding the selection visit * Subjects consuming dietary supplements * Subjects refusing to follow the dietary instructions on the 3 days preceding the test day