Graft failure is a lethal complication after allogeneic stem cell transplantation, which often need a salvage transplantation. However, the current outcome of second transplantation for graft failure is far from satisfactory. We performed a prospective single-arm study to investigate the safety and efficacy of a novel regimen.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
12
1. Change another donor 2. conditioning regimen: FLU/CY/anti-CD25 moAb
Peking University People's Hospital
Beijing, Beijing Municipality, China
RECRUITINGengraftment
Engraftment of neutrophils was defined as the first of 3 consecutive days when the absolute neutrophil count achieved 500/uL.
Time frame: 28 days after second transplantation
TRM at 28 day
treatment-related mortality(TRM) was defined as death from any cause other than relapse.
Time frame: 28 days after second transplantation
TRM at 100d
treatment-related mortality(TRM) was defined as death from any cause other than relapse.
Time frame: day 100 after second transplant
Overall survival at 100d
Overall survival at 100d
Time frame: day100 after second transplantation
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