Combination HTNV and PUUV DNA Vaccine

Inclusion Criteria: * Healthy adult male or nonpregnant, nonlactating female, ages 18-49 (inclusive) at time of screening * Have demonstrated adequate comprehension of the protocol by achieving a score of at least 80% correct on a short multiple-choice quiz. Individuals who fail to achieve a passing score on the initial quiz will be given the opportunity to retest after a review of the protocol information. Individuals who fail the quiz for the second time will not be enrolled. * Have provided written informed consent before screening * Subject is in good health as determined by past medical history, medication use, and abbreviated physical examination * Good health is defined by the absence of any medical condition described in the exclusion criteria in a subject with a normal abbreviated physical examination including vital signs. If the subject has another current, ongoing medical condition, the condition cannot meet any of the following criteria: (1) first diagnosed within 3 months of enrollment, (2) is worsening in terms of clinical outcome in last 6 months, or (3) involves need for medication that may pose a risk to subject's safety or impede assessment of adverse events or immunogenicity if they participate in the study. * An abbreviated physical examination differs from a complete physical examination in that it does not include a genitourinary and rectal examination. * Available and able to participate for all study visits and procedures * Sexually active men and women of childbearing potential must agree to use an effective method of contraception from 30 days prior to the first study vaccination until 6 months after the last study vaccination. * A sexually active man is defined as one whose partner is a woman of childbearing potential (see definition below) and has not had a vasectomy performed \> 1 year prior to screening. They must agree not to father a child until 6 months after the last vaccination. These subjects must agree to use a barrier method of birth control (eg, either condom with spermicidal foam/gel/film/cream or partner usage of occlusive cap \[diaphragm or cervical/vault caps\] with spermicidal foam/gel/film/cream/suppository). * Women of childbearing potential are defined as those who have not been sterilized via tubal ligation, bilateral oophorectomy, bilateral salpingectomy, hysterectomy, or successful Essure® placement (permanent, non-surgical, non-hormonal sterilization) with history of documented radiological confirmation test at least 90 days after the procedure and are still menstruating or \< 1 year of the last menses if perimenopausal. For this study, an effective contraceptive method is defined as one that results in a failure rate of less than 1% per year when it is used consistently and correctly (see the Manual of Procedures \[MOP\] for a list of acceptable methods). * Female subjects agree to not donate eggs (ova, oocytes), and male subjects agree to not donate sperm from the start of screening until at least 6 months after the last vaccination. * Negative hantavirus PsVNA test result at screening Exclusion Criteria: * History of prior infection with any hantavirus virus or prior participation in an HTNV, PUUV, or Andes virus vaccine trial. * Has plans to travel to an area with endemic Hantaan, Puumala, Seoul, and Dobrava virus transmission during the study. NOTE: Refer to the MOP for information on areas with endemic Hantaan, Puumala, Seoul, and Dobrava virus transmission * History of severe local or systemic reactions to any vaccine or vaccine products or a history of severe allergic reactions. * This includes a known allergy to an aminoglycoside (eg, gentamicin, tobramycin, neomycin, and streptomycin). * Is currently participating in or plans to participate in another study involving any investigational product (eg, vaccine, drug, or biologics) or a study that involves blood drawing, and/or an invasive procedure. * An invasive procedure includes endoscopy, bronchoscopy, or procedure requiring administration of IV contrast or removal of tissue. * Receipt or planned receipt of any live vaccination, experimental or otherwise, within the period 30 days prior to or after each vaccination and receipt or planned receipt of an inactivated vaccination, experimental or otherwise, within the period of 14 days prior to or after each vaccination. * Individuals, who based on clinical assessment by the investigator, have insufficient muscle mass to accommodate the 1 inch/25 mm penetration depth or have a skinfold thickness at eligible injection sites (deltoid region) that exceeds 40 mm. * Individuals in whom the ability to observe local reactions at the eligible injection sites (deltoid region) is, in the opinion of the investigator, unacceptably obscured due to a physical condition or permanent body art. * Presence of any surgical or traumatic metal implants at the injection site (medial deltoid muscles or overlying skin). * Screening laboratory results that are outside of the normal range (exceptions listed below) within 56 days prior to enrollment * Hemoglobin \> 11.0 g/dL for women; \> 12.9 g/dL for men * CBC (WBC and platelet) with differential either within institutional normal range or Grade 1 deviation from normal and deemed clinically insignificant * Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \< 1.25x upper limit of normal (ULN) * Serum creatinine ≤ ULN * Subjects with autoimmune disorders or chronic inflammatory disorders with a potential autoimmune correlation. * Receipt of immunoglobulins and/or any blood products within the 120 days preceding screening or planned administration during the study period * Donation of blood to a blood bank within 56 days prior to screening and at any time during the study period. * Subject seropositive for hepatitis B surface antigen (HBsAg) or hepatitis C antibodies (anti-HCV). * Any confirmed or suspected immunosuppressive or immunodeficient condition, including HIV infection, or use of anticancer chemotherapy or radiation therapy (cytotoxic) in the 3 years prior to screening.