A Study to Evaluate the Safety and Immunogenicity of Quadrivalent Influenza Vaccine

Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Either gender, aged 20 to 50 years old (inclusive) 3. Willing and able to comply with all the required study visits and follow-up defined by this protocol 4. Female subject with childbearing potential or male subject with female spouse/partner with childbearing potential must agree to use highly effective contraceptives from 15 days prior to vaccination until 60 days after vaccination. At least two forms of birth control must be adopted and one of which must be a barrier method. Acceptable forms include: * Established use of oral, injected or implanted hormonal methods of contraception * Placement of an intrauterine device (IUD) or intrauterine system (IUS) * Barrier methods of contraception: condom, or occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/cream/suppository Exclusion Criteria: 1. With previous known or potential exposure to influenza virus within 12 weeks prior to vaccination 2. Received seasonal influenza vaccine (registered or investigational) within 24 weeks prior to vaccination 3. Received any vaccine other than seasonal influenza vaccine within 6 weeks prior to vaccination 4. Received other investigational products (including medications and vaccines) within 6 weeks prior to vaccination 5. Administered immunoglobulins and/or other blood products within the 12 weeks prior to vaccination 6. Known or suspected hypersensitivity to any component of vaccines (including egg proteins); or history of allergy to consumption of eggs 7. History of inflammatory or degenerative neurological disease (e.g., Guillain-Barre syndrome) 8. With confirmed or suspected immunosuppressive or immunodeficient condition (e.g. HIV infection), or received \> 14 days of systemic steroid with equivalent dosage equal or over to 0.5 mg/kg/day prednisolone or other immune-modifying agents within 24 weeks prior to vaccination 9. Positive in HIV, HBsAg, or HCV test 10. With fever (defined as body temperature equal or over to 38 °C by any method) on the day of vaccination 11. With ongoing acute diseases or within the past 2 years serious medical conditions (e.g. concomitant illness) such as cardiovascular (e.g. New York Heart Association grade III or IV), hepatic (e.g. Child-Pugh Class C), psychiatric condition (e.g. alcoholism, drug abuse), medical history, physical findings, or laboratory abnormality that in the investigators' opinion could interfere with the results of the trial or adversely affect the safety of the subject 12. Female subject who is lactating or has positive serum or urine pregnancy test at screening or vaccination