Pharmacological Intervention for Symptomatic Snoring

Inclusion Criteria for Enrollment * Age 18-79 yrs * Self-reported habitual snoring ("most of the time" or "all of the time" on Snoring Self-Evaluation Scale) * Sleep-related symptoms defined by any of the following\*: * Visual-Analog Scale for Sleep Quality ≤7/10 ("reduced sleep quality") * Epworth Sleepiness Scale ≥10 ("excessive daytime sleepiness") * Functional Outcomes of Sleep Questionnaire \<18 ("reduced sleep-related quality of life"). * Presence of a bed-partner who is able to provide feedback to the participant on snoring (Snoring Bed-Partner Evaluation Scale) * The intention of these criteria is to enable participants with a broad range of possible snoring symptoms to be included. We note that the Visual-Analog Scale for Sleep Quality is, on average, approximately 7/10 in patients with sleep apnea; thus, we consider a value at or below 7 to indicate "reduced sleep quality". Exclusion Criteria for Enrollment * Known obstructive sleep apnea (OSA, except "mild") * Current treatment for OSA or snoring (continuous positive airway pressure, oral appliances, supplemental oxygen) * Use of medications expected to stimulate or depress respiration (including opioids, barbiturates, acetazolamide, doxapram, almitrine, theophylline, 4-hydroxybutanoic acid). * Use of similar medications to the study drugs. * Conditions likely to affect obstructive sleep apnea physiology: neuromuscular disease or other major neurological disorder, heart failure (also below), or any other unstable major medical condition. * Respiratory disorders other than sleep disordered breathing: o chronic hypoventilation/hypoxemia (awake oxygen saturation \< 92% by oximetry) due to chronic obstructive pulmonary disease or other respiratory conditions. * Other sleep disorders: periodic limb movements (periodic limb movement arousal index \> 10/hr), narcolepsy, or parasomnias. * Contraindications to the study drugs, including: * clinically-significant kidney disorders (eGFR\<60 ml/min/1.73m2) * clinically-significant liver disorders * clinically-significant cardiovascular conditions * severe hypertension (systolic blood pressure above 180 mmHg or diastolic below 110 mmHg measured at baseline) * cardiomyopathy (left ventricular ejection fraction, LVEF\<50%) or heart failure * advanced atherosclerosis * history of cerebrovascular events * history of cardiac arrhythmias e.g., atrial fibrillation, QT prolongation * other serious cardiac conditions * myasthenia gravis * pregnancy/breast-feeding We will not make new measurements of eGFR, LVEF or document their presence/absence for each participant. Criteria for Randomization After the baseline visit, the following criteria need to be met to continue participation: * Participants with AHI≥15 events/hr (moderate-to-severe OSA, hypopneas based on a 30% reduction in flow, accompanied by either a 3% oxygen desaturation or scored EEG-arousal) on the baseline study night, will not continue further participation after the baseline visit. * Participants must exhibit evidence of snoring during the baseline sleep study for further participation (mean tracheal sound intensity, Leq, exceeding 80 dB); the precise cutoff will be pilot tested in ongoing protocols (where snoring is routinely measured). Thus, strictly, the study population will include patients with symptomatic habitual snoring, with or without mild OSA (i.e. AHI\<5 and 5≤AHI\<15). We note that studies in patients with moderate-to-severe OSA have already been performed (AHI\>15), and further studies in this population are in progress. The inclusion of "mild OSA" will prevent a gap in the inclusion criteria for the investigation of the current intervention.