This study is design to assess two levels of dietary sodium intake in the treatment of patients with Acute Decompensated Heart Failure.
This study aim at assessing the effect of two levels of dietary sodium intake during seven days in hospitalized patients with Acute Decompensated Heart Failure. It is a prospective cohort, randomized, with blinded intervention groups: low sodium diet (the patients will receive 3 g/day of dietary sodium intake), and normal sodium diet (patients will receive 7 g/day of dietary sodium intake). Besides that, both groups will be submitted to a fluid intake limited to 1000 ml/day.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
44
Patients received low sodium diet (3g of sodium chloride/day) and a limit of fluid intake of 1000 ml/day.
Patients received normal sodium diet (7g of sodium chloride/day) and a limit of fluid intake of 1000 ml/day.
Hospital das Clínicas de Ribeirão Preto
Ribeirão Preto, São Paulo, Brazil
Serum sodium level at day 7
The difference of the absolute value of serum sodium between the groups in the final evaluation.
Time frame: 7 days
Occurrence of hyponatremia
The detection of serum level of sodium bellow 135 mmol/L
Time frame: on day 7
Change in body weight
The difference of the absolute value of body weight between the initial and final values.
Time frame: 7 days
Change in serum levels of NT-proBNP
The difference of the absolute value of NT-proBNP between the initial and final values, and between groups.
Time frame: 7 days
Change in systolic, diastolic and mean blood pressure
The difference of the absolute value of blood pressure between the initial and final values.
Time frame: 7 days
Change in heart rate
The difference of the absolute value of heart rate between the initial and final values.
Time frame: 7 days
Change in serum levels of creatinine
The difference of the absolute value of creatinine between the initial and final values.
Time frame: 7 days
Proportion of patients exhibiting worsening renal function (defined as increased serum creatinine> 0,3 mg / dL)
Time frame: 7 days
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Change in dyspnea sense
Using a visual anologic scale, with values between 0 and 10, where the minimum 0 is the greatest lack of air (worse) and the maximum 10 is the complete breath (better)
Time frame: 7 days
Change in well-being sense
Using a visual anologic scale, with values between 0 and 10, where the minimum 0 is the worse you ever felt (worse) and the maximum 10 is feel better than already (better)
Time frame: 7 days
Diuretic dosage and other drugs to ADHF during intervention period
What drugs will be used and the quantities.
Time frame: 7 days
Rate of hospital readmission
Time frame: 30 days
Rate of mortality after discharge
Time frame: 30 days