The objective of this study is to investigate the effect on postprandial glycaemia in a healthy population after intake of milk and oat based products.
Postprandial glycaemia, insulinaemia and GLP-1 will be measured after intake of test meals with equal amount of carbohydrates (adjusted using bread) and equal amount of total water.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
20
Commercially available white wheat bread
Developed reference product based on milk
Developed product based on full fat milk with addition of oat
Aventure AB
Lund, Sweden
Postprandial glycaemia capillary
Primary outcome is the difference in the two-hour incremental area under the curve (iAUC (0 - 120 min)) for capillary blood glucose between product 1-4 and the bread reference.
Time frame: 0-120 min after consumption
Postprandial glycaemia intravenous
The difference in the two-hour iAUC (0 - 120 min) for intravenous blood glucose between product 1-4 and the bread reference.
Time frame: 0-120 min
Postprandial Cmax capillary glucose
The difference in the three-hour Cmax (0 - 180 min) of capillary blood glucose between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial Cmax venous glucose
The difference in the three-hour Cmax (0 - 180 min) of intravenous blood glucose between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial glycaemia capillary
The difference in the three-hour iAUC (0 - 180 min) of capillary blood glucose between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial glycaemia venous
The difference in the three-hour iAUC (0 - 180 min) of intravenous blood glucose between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial glycaemia capillary
The difference in the one-hour iAUC (0 - 60 min) of capillary blood glucose between product 1-4 and the bread reference.
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Developed product based on skim milk with addition of oat giving a high fiber content to the product
Developed product based on skim milk with addition of oat giving a lower fiber content to the product
Time frame: 0-60 min
Postprandial glycaemia venous
The difference in the one-hour iAUC (0 - 60 min) of intravenous blood glucose between product 1-4 and the bread reference.
Time frame: 0-60 min
Postprandial glycaemia Tmax capillary
The difference in the Tmax (the time to maximum concentration) of capillary blood glucose between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial glycaemia Tmax venous
The difference in the Tmax of intravenous blood glucose between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial insulinaemia
The difference in the three-hour iAUC (0 - 180 min) of intravenous blood insulin between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial insulinaemia
The difference in the two-hour iAUC (0 - 120 min) of intravenous blood insulin between product 1-4 and the bread reference.
Time frame: 0-120 min
Postprandial insulinaemia
The difference in the one-hour iAUC (0 - 60 min) of intravenous blood insulin between product 1-4 and the bread reference.
Time frame: 0-60 min
Postprandial insulinaemia Cmax
The difference in the three-hour Cmax (0 - 180 min) of intravenous blood insulin between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial insulinaemia Tmax
The difference in the Tmax of intravenous blood insulin between product 1-4 and the bread reference.
Time frame: 0-180 min
Postprandial GLP-1 bread reference
The difference in the one-hour iAUC (0 - 60 min) of intravenous blood GLP-1 between product 1-4 and the bread reference.
Time frame: 0-60 min
Postprandial GLP-1, yoghurt control
The difference in the one-hour iAUC (0 - 60 min) of intravenous blood GLP-1 between products 2-4 and product 1.
Time frame: 0-60 min
Postprandial GLP-1 Cmax bread reference
The difference in the one-hour Cmax (0 - 60 min) of intravenous blood GLP-1 between product 1-4 and the bread reference.
Time frame: 0-60 min
Postprandial GLP-1 Cmax yoghurt control
The difference in the one-hour Cmax (0 - 60 min) of intravenous blood GLP-1 between products 2-4 and product 1.
Time frame: 0-60 min