BFR and Muscle Mitochondrial Oxidative Capacity

Inclusion Criteria. 1. Capable and willing to give written informed consent 2. Capable of understanding inclusion and exclusion criteria 3. 18-40 years of age inclusive 4. Body Mass Index (BMI) between 18.5-30 kg/m2 inclusive 5. No medical condition that would limit their participation in supervised exercise training based on the Physical Activity Readiness Questionnaire for Everyone (PARQ+) 6. No current prescription medications, with the exception of birth control 7. Willing to allow researchers to use data, biospecimens (e.g., blood) and images (e.g., Dual Energy x-Ray Absorptiometry) for research purposes after study participation is completed Exclusion Criteria. 1. Evidence or self-report being pregnant, lactating, or anticipating becoming pregnant in the next year 2. Participation in resistance or aerobic exercise training \> 2 days per week within the 3 months prior to screening 3. Self-report of history of type 1 or 2 diabetes mellitus 4. Self-report history of cardiovascular, peripheral vascular, cerebral vascular, pulmonary, or renal disease 5. Self-report or evidence of uncontrolled hypertension 6. Self-report history of blood clotting disorders 7. Self-report history of deep vein thrombosis or pulmonary embolism 8. Self-report history of sickle cell trait 9. Self-report history of varicose veins 10. Self-report history of a myopathy leading to muscle loss, weakness, severe cramps or myalgia 11. Self-report history of orthopedic limitations that would preclude them from participation in a dynamic exercise program 12. Self-report history of musculoskeletal disorders (e.g., severe osteoarthritis, rheumatoid arthritis, avascular necrosis or osteonecrosis) 13. Self-report history of neurological disorders (e.g., peripheral neuropathy, amyotrophic lateral sclerosis, multiple sclerosis, fibromyalgia, Parkinson's disease) 14. Weight loss of \> 10% in the last 3 months prior to screening 15. Active smoking 16. Current consumption of \> 14 alcoholic drinks per week based on self-report 17. Absolute Contraindication to Exercise as Defined by the American College of Sports Medicine,1 including: 1. Resting diastolic blood pressure \> 100 mm Hg 2. Resting systolic blood pressure \> 180 mm Hg 3. Resting heart rate \> 100 beats per min 18. Self-report acute viral or bacterial upper or lower respiratory infection at screening 19. Any other condition that in the judgement of the Principal Investigator and/or the Medical Director of this protocol may interfere with study participation and adherence to the protocol