Compensatory Brain Mechanisms for Amygdala-associated Cognitive Dysfunction: Potential Role of the Cortical Mirror Neuron System

University of Electronic Science and Technology of China350 enrolled

Overview

Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI.

In the present study, investigators aim to investigate amygdala dysfunction \& potential compensation in individuals with high and low traits (e.g. Autism, Anxiety, Depression traits, Alexithymia), high and low stress or protective factors in the environment (social network, early life stress) and different molecular genetic make-up. On the neural level, functional and structural connectivity as well as task-related BOLD activation will be assessed.

Study Type

OBSERVATIONAL

Enrollment

350

Conditions

Healthy

Interventions

screen high and low triat subjectsBEHAVIORAL

use a range of questionniares to screen screen high and low triat subjects (eg. Autism, Anxiety, Depression traits and social network size)

Eligibility

Sex: ALLMin age: 17 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy subjects Exclusion Criteria: * history of head injury * claustrophobia; * medical or psychiatric illness * female subjects were pregnant or taking oral contraceptives. * taking any form of medication and drunk any caffeine-containing beverages on the day of the experiment.

Locations (1)

China, Sichuan

Chengdu, Sichuan, China

RECRUITING

Outcomes

Primary Outcomes

brain activity and connectivity during social and cognitive tasks

brain activity and connectivity was measured by the fMRI scanner

Time frame: 2 hours

Central Contacts

Keith Kendrick, Dr.

CONTACT

k.kendrick.uestc@gmail.com

Data from ClinicalTrials.gov

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