An Ascending Multiple Dose Study With VTP-43742 in Healthy Volunteers

Inclusion Criteria: * Healthy males or females, 18 to 45 years of age, inclusive. * Body weight of at least 55 kg and body mass index of 18-32 kg/m2, inclusive. * Medically healthy with clinically insignificant screening results. * Women of child-bearing potential (WOCBP) AND men with partners who are WOCBP must agree that they and/or their partner will use two reliable forms of contraception as per study requirements * WOCBP must have a negative serum β-hCG pregnancy test at the Screening and Baseline visit. * Voluntarily consent to participate in the trial Exclusion Criteria: * Unwilling or unable to provide written informed consent * History or presence of significant cardiovascular, pulmonary, hepatic, renal, hematologic, coagulation, gastrointestinal, endocrine, immunologic, dermatologic, neurologic, or psychiatric disease * Evidence of organ dysfunction or any clinically significant deviation from normal in vital signs, physical examination, clinical laboratory determinations or ECG * Any major surgery within 3 months of Screening * Positive urine drug/alcohol testing at Screening or Baseline visit * Use of tobacco and/or nicotine-containing products within 3 months prior to the start of dosing of the trial * Positive testing for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C antibodies (HCV Ab) at Screening * History or presence of alcoholism or drug abuse as defined in DSM V, Diagnostic Criteria for Drug and Alcohol Abuse * History of hypersensitivity or idiosyncratic reaction to drugs from multiple drug classes * Any previous gastrointestinal surgery or recent (within 3 months) history of gastrointestinal disease that could impact the absorption of the study drug * Blood donation or significant blood loss within 8 weeks prior to Day 1 of the trial * Plasma donation within 7 days prior to Day 1 of the trial * Blood transfusion within 4 weeks of Screening * Positive serum pregnancy test (WOCBP) at the Screening or Baseline visit * Prisoners or subjects who are compulsorily detained (involuntarily incarcerated) for treatment of either a psychiatric or physical disease (e.g., infectious disease) must not be enrolled into this study * Any other medical, psychiatric, and/or social reason as determined by the Investigator