There are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people. The purpose of the present study is to assess the effects on muscle mass and function, tendon and bone of two different training intensities, light-moderate vs. heavy load, in people older than 65 years old. The study will be carried out with a randomized controlled design. Participants will perform single training sessions and a 12-wk dynamic resistance training program on the knee extensors with different training intensities on each leg. One leg will train with heavy loads and the other one will train with light-moderate loads, but matching the load x repetitions performed by the contralateral side.
The decline in muscle function provoked by the aging process and frailty are directly related to decreases in mobility and the ability to perform the so called "daily life activities". Resistance training is especially useful at this stage, given that it is an effective and widely applicable intervention to control and revert sarcopenia, and the deterioration of tendon and bone function. Despite of the effectiveness of heavy load resistance training, a controversy has arisen in the last years about the effects of lower load resistance training programs to achieve similar adaptations. This is because most of the studies that have compared light-moderate versus heavy load programs did not control the differences in total training load, measured as the overall mechanical work performed during the training program. Therefore, there are no unbiased studies that have analyzed the effects of resistance training with traditional, heavy versus light-moderate loads on muscle, tendon and bone in elderly people. The purpose of the present study is to assess the effects on muscle mass and function, tendon and bone of two different training intensities, light-moderate vs. heavy load, in people older than 65 years old. The studies will be carried out with a crossover (acute training sessions) and randomized controlled design (longitudinal training intervention). Participants will perform single training sessions with each resistance training intensity and a 12-wk dynamic resistance training program on the knee extensors with different training intensities on each leg. One leg will train with heavy loads and the other one will train with light-moderate loads, but matching the load x repetitions performed by the contralateral side. Muscle adaptations (EMG, muscle size and architecture), tendon mechanical properties, bone mineral density, blood parameters and life quality will be analyzed before and after the cessation of the training program.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
55
High intensity resistance training (80% of 1 repetition maximum), 2 d/wk (Longitudinal)
Light-moderate intensity resistance training (40% of 1 repetition maximum), 2 d/wk (Longitudinal)
No resistance training during the intervention period.
High intensity resistance training, 1 training session
Light-moderate intensity resistance training, 1 training session
Universidad de Castilla-La Mancha, Laboratorio de Actividad Física y Función Muscular. Campus de la Fábrica de Armas. Avda. Carlos III s/n
Toledo, Spain
Acute change in muscle size (cross sectional area, cm2)
Ultrasound-based determination quadriceps muscle size and architecture.
Time frame: Change from baseline at 5 minutes after a training session
Change in muscle size (cross sectional area, cm2)
Ultrasound-based determination quadriceps muscle size and architecture.
Time frame: Change from baseline to week 12
Acute change in muscle function (N)
Force-velocity profile of the single-leg press exercise
Time frame: Change from baseline at 5 minutes after a training session
Change in muscle function (N)
Force-velocity profile of the single-leg press exercise
Time frame: Change from baseline to week 12
Change in patellar tendon stiffness (N/mm)
Ultrasound and force-based measures of tendon mechanical properties.
Time frame: Change from baseline to week 12
Acute change in patellar tendon stiffness (N/mm)
Ultrasound and force-based measures of tendon mechanical properties.
Time frame: Change from baseline at 5 minutes after a training session
Change in muscle mass (kg)
Lean mass determined by Dual energy X-ray absorptiometry
Time frame: Change from baseline to week 12
Change in bone mass (g)
Bone mineral content determined by Dual energy X-ray absorptiometry
Time frame: Change from baseline to week 12
Acute change in muscle excitation (mV)
Electromyographic activity of the knee extensor and flexor muscles during strength assessment and training
Time frame: Change from baseline at 5 minutes after a training session
Change in muscle excitation (mV)
Electromyographic activity of the knee extensor and flexor muscles during strength assessment and training
Time frame: Change from baseline to week 12
Change in physical function
Short Physical Performance Battery
Time frame: Change from baseline to week 12
Blood analysis: Acute change in oxidative stress
Carbonyl proteins (plasma concentration)
Time frame: Change from baseline at 5 minutes after a training session
Blood analysis: Change in oxidative stress
Carbonyl proteins (plasma concentration)
Time frame: Change from baseline to week 12
Blood analysis: Acute change in Inflammation
Interleukin 6, Tumoral necrosis factor Alpha, C reactive protein (plasma concentration)
Time frame: Change from baseline at 5 minutes after a training session (Acute)
Blood analysis: Change in inflammation
Interleukin 6, Tumoral necrosis factor Alpha, C reactive protein (plasma concentration)
Time frame: Change from baseline to week 12
Blood analysis: Acute change in anabolic processes
Testosterone, growth hormone, Insulin growth factor-1 (plasma concentration)
Time frame: Change from baseline at 5 minutes after a training session
Blood analysis: Change in anabolic processes
Testosterone, growth hormone, Insulin growth factor-1 (plasma concentration)
Time frame: Change from baseline to week 12
Blood analysis: Acute change in catabolic processes
Cortisol, Creatin kinase (plasma concentration)
Time frame: Change from baseline at 5 minutes after a training session
Blood analysis: Change in catabolic processes
Cortisol, Creatin kinase (plasma concentration)
Time frame: Change from baseline to week 12
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