JY028 Single Vitreous Injection in a Phase 1 Clinical Trial in nAMD Patients

Inclusion Criteria: 1\. The patient volunteered to participate and signed the informed consent 2. No more than 50 years of age and less than 75 years of age, male or female 3. Diagnosed as nAMD 4. The optimal corrected visual acuity of the target eye ETDRS should be no more than 50 letters, and the optimal corrected visual acuity of the opposite eye should be no more than 34 letters 5. The target eye pressure is no more than 25mmHg, which can be controlled by drugs 6. A normal coagulation function: the platelet count is 100 x 10 \^ 9-300x 10\^10 / L, thrombin time, prothrombin time within the normal range. \- Exclusion Criteria: 1. Choroid polypoid angiopathy (PCV) 2. There are other obvious eye diseases/conditions (such as diabetic retinopathy, cataract, abnormal eyelid, uncontrolled glaucoma, eye active inflammation, etc.) 3. CNV caused by other causes other than nAMD, such as diabetic retinopathy, vascular stripe disease, ocular histoplasmosis, case myopia, trauma, etc 4. The target eye has received any intraocular surgery or laser therapy within 3 months prior to enrollment 5. Any eye treated with antiangiogenic drugs within 3 months prior to baseline visit 6. Patients with active eye infections, such as conjunctivitis, keratitis, sclerotic, blepharitis, endophthalmitis or uveitis 7. Persons with a history of myocardial infarction and/or cerebral infarction or other active or acute cardiovascular diseases 8. HIV antibody/hiv-p24 antigen, any of the positive subjects in the treponema pallidum antibody 9. Active HBsAg carriers (conditions must be met: HBsAg positive, HBV DNA positive, ALT higher than normal upper limit) 10. Patients with HCV (the following conditions must be met: lgM positive anti-hcv antibody, ALT higher than the upper limit of normal value) 11. Fluorescein sodium allergy 12. Allergy to anti-vegf monoclonal antibodies or humanized monoclonal antibodies 13. Patients who participated in other clinical trials within 3 months 14. Patients who took NSAIDs and aspirin or other anticoagulant or platelet drugs within 1 month before enrollment 15. An unhealed wound, ulcer, fracture, or other related medical condition 16. Patients with uncontrollable hypertension, with systolic blood pressure of \> 140mmHg and diastolic blood pressure of \> 90mmHg 17. Patients with uncontrollable clinical diseases or problems (such as serious mental, neurological, cardiovascular, respiratory and other systemic diseases and malignant tumors) 18. Pregnant and lactating women and those who cannot take contraceptive measures 19. According to the researcher, it is not suitable for the candidate -