1. To evaluate hepatic fibrosis and steatosis using MR imaging, transient elastography (TE), and serum biomarker 2. To develop non-invasive diagnosis marker for NASH and advanced fibrosis
As nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver disease, non-invasive diagnosis of disease severity in NAFLD is urgently needed. In this study, the investigators compared hepatic fibrosis and steatosis using MR imaging and transient elastography (TE) and tried to find non-invasive diagnostic marker for NASH and advanced fibrosis. This is a multicenter prospective study of patients with biopsy-proven NAFLD. The patients were underwent laboratory test, liver biopsy, MRI and TE within 6 months of enrollment. MRI examination included MR spectroscopy (MRS), and MR elastography (MRE). TE measured liver stiffness and controlled attenuation parameter (CAP).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
150
Imaging evaluation: Fibroscan, MRI scan for evaluation of fibrosis and steatosis in biopsy proven NAFLD patients Serologic evaluation: serologic test for evaluation of fibrosis and steatosis in biopsy proven NAFLD patients
Korea University Guro Hospital
Seoul, South Korea
RECRUITINGDevelopment of scoring system for diagnosis of NASH
Development of scoring system for diagnosis of NASH using cox regression analysis
Time frame: up to 24 months
Evaluation of hepatic fibrosis using fibroscan
Assessment of hepatic fibrosis using fibroscan with transient elastography (kilopascals) (kPa)
Time frame: up to 24 months
Evaluation of hepatic steatosis using fibroscan
Assessment of hepatic steatosis using fibroscan with CAP (Controlled Attenuation Parameter) (dB/m)
Time frame: up to 24 months
Evaluation of hepatic fibrosis using MRI
Assessment of hepatic fibrosis using MRI with MR elastography (MRE) (kPa)
Time frame: up to 24 months
Evaluation of hepatic steatosis using MRS
Assessment of hepatic steatosis using fibroscan with MR spectrography (MRS) (%)
Time frame: up to 24 months
Evaluation of hepatic fibrosis using serologic marker
Assessment of hepatic fibrosis using AST to Platelet Ratio Index (APRI)
Time frame: up to 24 months
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