Effect of Camel Milk on Insulin and Incretin Response

Imperial College London Diabetes Centre15 enrolled

Overview

To examine the differential effect of camel and cow milk on the physiological response, to a liquid mixed-meal challenge, in people with normal glucose tolerance

Camel milk is used as a traditional remedy throughout the Middle East and Indian Subcontinent for conditions such as type 2 diabetes and dyslipidemia. It is currently unclear how such an effect could be mediated in vivo and studies are limited. We performed this study as a pilot experiment to assess the effects of camel milk on Insulin, Glucose, GLP-1, C-peptide and Lipid profile.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Insulin Sensitivity Glucose Tolerance

Interventions

Camel milkDIETARY_SUPPLEMENT

Camel Milk administered 10 minutes before a mixed meal of carbohydrate and protein; 2-week washout between interventions

Cow milkDIETARY_SUPPLEMENT

Cow milk administered 10 minutes before a mixed meal of carbohydrate and protein;2-week washout between interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal glucose tolerance * BMI \< 30 kg/m2 Exclusion Criteria: * Type 1 diabetes mellitus * Type 2 diabetes mellitus * Impaired fasting glucose or impaired glucose tolerance * Lactose intolerance * Weight loss / gain ≥ 5 kg in the preceding two months * Use of estrogenic drugs or corticosteroids * Known hypertriglyceridemia requiring treatment * History of heart attack, angina or cardiovascular disorder * History of malignant tumor * Pregnant or lactating women * Hemoglobin \< 12 for any reason * Recent surgery or major hemorrhage * History of bariatric or metabolic surgery

Locations (1)

Imperial College London Diabetes Centre

Abu Dhabi, United Arab Emirates

RECRUITING

Outcomes

Primary Outcomes

Glucose response to camel and cow milk

The difference between interventions in terms of peak of glucose

Time frame: 5 months

Response of glucose to camel and cow milk

The difference between interventions in terms of area under the curve

Time frame: 5 months

Secondary Outcomes

Insulin response to camel and cow milk

The difference between interventions in terms of peak

Time frame: 5 months

Response of insulin to camel and cow milk

The difference between interventions in terms of area under the curve

Time frame: 5 months

GLP-1 response to camel and cow milk

The difference between interventions in terms of peak

Time frame: 5 months

Response of GLP-1 to camel and cow milk

The difference between interventions in terms of area under the curve

Time frame: 5 months

C-peptide response to camel and cow milk

The difference between interventions in terms of peak

Time frame: 5 months

Response of C-peptide to camel and cow milk

The difference between interventions in terms of area under the curve

Time frame: 5 months

Data from ClinicalTrials.gov

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