Outcome of Different Pathogenic Mutations in Hypertrophic Cardiomyopathy

Inclusion Criteria: * 1\. Adults: a wall thickness ≥15 mm in one or more LV myocardial segments-as measured by any imaging technique (echocardiography, cardiac magnetic resonance imaging (CMR) or computed tomography (CT))-that is not explained solely by loading conditions; * 2\. Children: an LV wall thickness more than two standard deviations greater than the predicted mean (z-scored\>2, where a z-score is defined as the number of standard deviations from the population mean); * 3\. Relatives: the first-degree relatives of patients with unequivocal disease (LVH ≥15 mm) is based on the presence of otherwise unexplained increased LV wall thickness ≥13 mm in one or more LV myocardial segments, as measured using any cardiac imaging technique \[echocardiography, cardiac magnetic resonance (CMR) or CT\]. Exclusion Criteria: * 1\. Patients with severe valvular disease, aortic stenosis, congenital heart disease, hypertensive heart disease, diabetic cardiomyopathy, or other cardiovascular or systemic diseases that may cause ventricular hypertrophy; * 2\. Patients who had participated in any clinical trial during the first 3 months; * 3\. Previous history of cancer or tumor, or pathological examination confirmed precancerous lesions (such as breast ductal carcinoma in situ, or atypical hyperplasia of the cervix); * 4\. Patients refused to comply with the requirements of this study to complete the research work.