Optimized Characterization of Takotsubo Syndrome by Obtaining Pressure Volume Loops

University of Luebeck25 enrolled

Overview

Aim of this prospective study is to assess the pathophysiology of Takotsubo Syndrome by obtaining pressure volume loops with conductance catheters, which allows detailed conclusions regarding systolic and diastolic hemondynamics and subsequently regarding potential underlying mechanisms

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Takotsubo Syndrome

Interventions

Measurements of left ventricular pressure and volumeDIAGNOSTIC_TEST

Patients with suspected Takotsubo syndrome (typical ballooning in left ventriculography without significant obstructive coronary artery disease that sufficiently explains the contraction abnormalities) will undergo continuous online measurements of left ventricular pressure and volume using conductance catheters. Cardiac magnetic resonance (CMR) imaging will be performed in patients without contraindications for optimized morphological characterization and exclusion of important differential diagnoses.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Confirmed Takotsubo syndrome according to current diagnostic criteria including complete normalization of left ventricular function during follow-up * Sinus rhythm during invasive measurements * Age ≥18 years * Written informed consent Exclusion Criteria: * Cardiogenic shock * Signs of myocarditis or myocardial infarction with spontaneous lysis of thrombus in cardiac magnetic resonance imaging * Pregnancy * Participation in another trial

Locations (1)

Medical clinic II-UKSH

Lübeck, Schleswig-Holstein, Germany