Recent studies have suggested that the use of left ventricular ejection volume index calculation may aid in the hemodynamic management of critically ill patients. However, a prospective and randomized comparison in patients with heart failure for inotropic dose adjustment has not been described. The objective of this study was to evaluate the efficacy and safety of ejection volume index versus liberal strategy in adjusting dobutamine dose in patients with heart failure and low cardiac output. Methodology: A unicentric, randomized and prospective study will be performed in a comparative manner. Hospital data (test results, medical outcomes, dobutamine dose, complications) of patients will be analyzed for safety and effectiveness. Expected results: The use of ejection volume index is not inferior to the liberal strategy in the initial adjustment of the dose of dobutamine in patients with heart failure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
adjust dobutamine dose
adjust dobutamine dose
base excess levels
serum analysis
Time frame: 24 hours
bicarbonate levels
serum analysis
Time frame: 24 hours
systolic and diastolic blood pressure
physical evaluation
Time frame: 24 hours
cardiac output
echocardiography echocardiography
Time frame: 24 hours
systolic volume
echocardiography
Time frame: 24 hours
urinary output
urine analysis
Time frame: 24 hours
arterial lactate levels
serum analysis
Time frame: 24 hours
central venous oxygen saturation levels
serum analysis
Time frame: 24 hours
BNP levels
plasma analysis
Time frame: 24 hours
troponin levels
serum analysis
Time frame: 24 hours
heart rate
physical evaluation
Time frame: 24 hours
creatinine levels
serum analysis
Time frame: 24 hours
urea levels
serum analysis
Time frame: 24 hours
occurrence of sustained ventricular arrhythmia
electrocardiography
Time frame: 24 hours
need for orotracheal intubation
Time frame: 24 hours
need for vasopressor or other inotropic association
hipotension
Time frame: 24 hours
need for mechanical circulatory assistance
Time frame: 24 hours
lowering of consciousness level
glasgow \< 14
Time frame: 24 hours
cardiorespiratory arrest
Time frame: 24 hours
worsening of renal function
increase 0.5 mg / dl in relation to admission creatinine
Time frame: 24 hours
death
Time frame: 24 hours
failure of dobutamine weaning up
Time frame: 7 days
hospitalization time
Time frame: 30 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.