This study explores the feasibility of applying an intervention using vegetable oils (coconut and sunflower oils) on individuals diagnosed with Mild Cognitive Impairment. Participants will be divided into two groups and will either receive 30 ml of coconut or sunflower oil to be consumed daily for six months.
Research has shown that some forms of dementia associated to ageing can often be linked to low levels of sugar in the brain. Which may cause damage to the brain nerve cells. The main source of fuel for the brain comes from sugar in the form of glucose. Providing an additional source of fuel to brain cells may reduce the damage, potentially preventing further decline of dementia in individuals with Mild Cognitive Impairment (MCI). This study explores the possibility of using vegetable oils (coconut and sunflower oils) as an additional source of energy to individuals diagnosed with Mild Cognitive Impairment. The researchers will use different tests to evaluate if the study could be done. Participants will be divided into two groups and will either receive 30 ml of coconut or sunflower oil to be consumed daily for six months. The researchers will visit participants in their houses over three times during the study to collect the data. During each visit, the researcher will conduct blood test in which blood will be collected by pricking the finger of participants to check their blood ketone levels. Paper pencil and/or computer tasks will be completed to measure the cognitive abilities (e.g. attention, orientation and learning) of participants. Participants will also be asked to complete a food diary in which they will provide details of their diet and eating habits. Moreover, they will be asked to provide feedback on the study by answering a set of questions either during an interview or by completing a feedback form. The information collected during these visits will be used to evaluate the study. Results from this study would help determine whether such an intervention can be undertaken in adults with MCI. The study will provide information related to the practicality of using vegetable oils on adults with MCI. This would provide the evidence to develop a larger study that would allow us to systematically evaluate the effect of vegetable oils on MCI. Which would further enable us to develop an intervention that might possibly improve the brain functions of adults with MCI and maintain their quality of life for longer by delaying the development of dementia and reducing the progression from MCI to AD (Alzheimer's disease) in adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
34
Participants will receive 30 ml of virgin coconut oil to replace their normal oil intake for a period of 6 months.
Participants will receive 30 ml of sunflower oil to replace their normal oil intake for a period of 6 months.
Bournemouth University
Bournemouth, Dorset, United Kingdom
Vegetable oil usage
the amount of oil used by individuals (ml) will be monitored
Time frame: 6 months
Overall cognition
Assessed by Mini Addenbrookes Cognitive Examination (mACE) which has a high score of 30 with higher scores indicating better cognition.
Time frame: Six months
Quality of life of adults with Mild cognitive impairment measured by ADCS-MCI-ADL (Alzheimer's Disease Cooperative Study Mild Cognitive Impairment- Activities of Daily Living)
Quality of life of participants measured by ADCS-MCI-ADL (Alzheimer's Disease Cooperative Study Mild Cognitive Impairment- Activities of Daily Living) questionnaire, it has a score that rages from 0 to 53; higher score are linked to better quality of life.
Time frame: six months
Dietary intake assessed by four day food records using Nutritics software
Dietary energy and macronutrient (carbohydrate, fat and protein) intake assessed by four day food records using Nutritics software (https://www.nutritics.com/p/references).
Time frame: six months
Blood samples (beta hydroxyl butyrate):
ketone bodies concentrations (mmol) will be assessed by Abbott freestyle Optium Neo, ketone meter.
Time frame: six months
Executive measure
Assessed by trail making test B that has an average score of 75 seconds and a deficient score of \> 273 seconds
Time frame: six months
Verbal Memory
Verbal memory will be assessed by word list test which is a subtest of the Wechsler Memory Scale III; the lower the test score the higher the cognitive impairment.
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Time frame: six months
Verbal Fluency
Verbal Fluency test in which a score lower than 17 shows cognitive impairment (the higher the score the better the cognition) will be used to determine
Time frame: six months
Processing Speed
Digit symbol test in which lower test scores are correlated with higher impairment will be used to assess processing speed
Time frame: six months
Attention
Digit Span test will be used to assess attention, the lower the score the higher the impairment.
Time frame: six months
Visual Spatial memory
Supermarket task will be used to asses the visual spatial memory of participants, the score depends on the time required to complete the task. Extra time is related to higher cognitive impairment.
Time frame: six months