Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients

N/AEnrolling By InvitationNCT03727399

Mabylon AG300 enrolled

Overview

The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients. Patient samples suitable for antibody cloning are selected based on seroprofiling for the respective allergens. The study aims at isolating lymphocytes from patients with potential allergen-neutralizing IgG in serum and to clone antibodies from antibody gene sequences obtained from B cells of those patients.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Pollen Allergy

Interventions

blood withdrawalOTHER

Blood withdrawal

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * History of allergic rhinitis, conjunctivitis or asthma due to sensitization to grass- or birch Allergens * Male or female patients older than 18 years * Written informed consent for providing blood and also to allow experimental manipulation Exclusion Criteria: * Age \< 18 years * Any corticosteroids within the last three days * Oral corticosteroid therapy within the last ten days * Parenteral depot corticosteroids within the last three months

Locations (1)

Immunologie Zentrum Zürich

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Antibody profiling

Analysis and IgG profiling of specific antibodies binding major grass- and tree-pollen allergens in allergic patients.

Time frame: October 2018 - September 2021

Data from ClinicalTrials.gov

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