Efficacy of Treatment Sequences in Patients With Non-small Cell Lung Cancer Receiving Lorlatinib

Intergroupe Francophone de Cancerologie Thoracique291 enrolled

Overview

The study will evaluate progression-free survival, overall survival, best response and duration of treatment in patients with advanced ALK- and ROS1-positive non-small cell lung cancer who received lorlatinib as part of the French expanded access program.

IFCT-1803 LORLATU study will evaluate progression-free survival, overall survival, best response and duration of treatment in patients with advanced ALK- and ROS1-positive non-small cell lung cancer who received lorlatinib (PF-06463922) as part of the French expanded access program. Those outcomes will be correlated to clinical, pathological, and radiological characteristics of patients.

Study Type

OBSERVATIONAL

Enrollment

291

Conditions

Non-small Cell Lung Cancer Metastatic ALK Gene Rearrangement Positive ROS-1 Gene Rearrangement Positive

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with histologically or cytologically confirmed locally advanced or metastatic NSCLC (Stage IIIB or IV accordingly to American Joint Committee on Cancer \[AJCC\] classification) at time of lorlatinib initiation * Patients who received at least one week of treatment with lorlatinib as part of the French Expanded Access Program (ATU program); ATU was granted due to their inability to meet eligibility criteria for on-going recruiting trials, inability to participate in other clinical trials (e.g., poor performance status, lack of geographic proximity), or because other medical interventions are not considered appropriate or acceptable. Exclusion Criteria: * Patients enrolled in a lorlatinib clinical trial

Locations (30)

Aix-en-Provence - CH

Aix-en-Provence, France

Outcomes

Primary Outcomes

Progression free survival

time from first dose of treatment to first occurrence of disease progression or death from any cause during the study