Xpert MTB/XDR Clinical Evaluation Trial

Inclusion Criteria: * • Age 18 years or above; * Symptoms suggesting pulmonary TB, i.e. persistent cough (generally ≥3 weeks or as per local definition of TB suspect), and at least one of the following: * Previously received \>1 month of treatment for a prior TB episode or * Failing TB treatment with positive sputum smear or culture after ≥3 months of a standard TB treatment or * Had close contact with a known drug-resistant TB case or * Newly diagnosed with MDR-TB within the last 30 days or * Previously diagnosed with MDR-TB and failed TB treatment with positive sputum smear or culture after ≥3 months of a standard MDR-TB treatment regimen Patients meeting the above criteria will be screened by Xpert MTB/RIF or Xpert MTB/RIF Ultra. TB patients meeting the following criteria will be included in the study: * A clear Mtb-positive and RIF-resistant or RIF-sensitive result by Xpert MTB/RIF or Xpert MTB/RIF Ultra * Provision of informed consent; * Production of an adequate quantity (\>3mL) of sputum Exclusion Criteria: * Participants will be excluded from the study if informed consent is not provided.