This study is aimed to understand the clinical characteristics, etiology and resistance phenotype of major pathogens of SCAP in China through multicenter and prospective investigation. Thus to provide epidemiological basis for improving the SCAP diagnosis and treatment protocol suitable for China.
During the study period, all patients who are diagnosed with SCAP and meet the inclusion criteria in the participating unit should be enrolled in the study . At the end of the trial, each participating unit should complete at least 20 qualified cases, and all participating units should have a total of more than 300 qualified cases. 1. Learn about the etiology of SCAP in China. 2. Grasp the resistance phenotype and molecular epidemiology of major pathogens of SCAP in China. 3. Know the important clinical characteristics of SCAP in China, including age, basic diseases, length of hospital stay, length of stay in ICU, duration of mechanical ventilation, clinical manifestations, imaging findings, complications, mortality, etc. 4. Analyze and clarify the clinical risk factors of affecting SCAP mortality. 5. Understand the current situation of antibiotic treatment of SCAP in China.
Study Type
OBSERVATIONAL
Enrollment
300
Ruijin Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
RECRUITINGMicrobiological profile of lower respiratory tract specimens
Record the microbiological profile of lower respiratory tract specimens, including sputum, nasopharyngeal swabs, tracheobronchial aspirates and BAL fluid.
Time frame: Day 0 of the study
Microbiological profile of urine specimens
Record the microbiological profile of urine specimens, including all the bacteria explored,especially legionella or streptoccus pneumonia.
Time frame: Day 0 of the study
Microbiological profile of serum specimens
Record the microbiological profile of serum specimens , including all the bacteria explored, especially legionella, mycoplasma, chlamydia.
Time frame: Day 0,14 days or 21 days of the study
General conditions of the participants
Record the general conditions of the participants when included in the study ,such as demographic , clinical symptoms and signs of the participants, legionella contact history , enrollment date, ICU admitted condition, comorbidities, prior antibiotic treatment and so on.
Time frame: Day 0 of the study
Inflammatory Parameters
Record the levels of WBC, CRP, PCT of the participants.
Time frame: Day 0, 3 days of the study, and until the end of the study(approximately 1 year).
Arterial Blood Gas analysis of the participants
Record the arterial Blood Gas analysis(pH,PO2,PCO2 etc.) when included in the study.
Time frame: Day 0 of the study
Chest Image of the participants
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Record the chest radiograph of the participants when included in the study.
Time frame: Day 0 of the study
Pneumonia Severity Index of the participants
Record the pneumonia severity index of the participants according to the PSI scoring system,which has been used to decide whether patients with pneumonia can be treated as outpatients or as (hospitalized) inpatients.
Time frame: Day 0 of the study
CURB-65 Score of the participants
Assessment of consciousness, urea, respiratory rate, BP, and age 65 years score of the participants(Confusion-1,BUN\>7mmol/l-1,Respiratory rate≥30-1，SBP\<90mmHg,DBP≤60mmHg-1,Age≥65-1).The risk of death at 30 days increases as the score increases:0-0.6%,1-2.7%,2-6.8%,3-14.0%,4-27.8%,5-27.8%.
Time frame: Day 0 of the study
Prognosis of the SCAP participants
Record the prognosis(cure,improvement,invalid,recrudesce,death) of the participants through the study completion.
Time frame: up to 3 days of the study and until the end of the study(approximately 1 year).